Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 714862

Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia.


Braut, Tamara; Kujundžić, Milodar; Vukelić, Jelena; Manestar, Dubravko; Krstulja, Mira; Starčević, Radan; Grahovac, Blaženka
Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia. // Collegium antropologicum. Supplement, 36 (2012), Suppl 2; 87-91 (podatak o recenziji nije dostupan, članak, znanstveni)


CROSBI ID: 714862 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia.

Autori
Braut, Tamara ; Kujundžić, Milodar ; Vukelić, Jelena ; Manestar, Dubravko ; Krstulja, Mira ; Starčević, Radan ; Grahovac, Blaženka

Izvornik
Collegium antropologicum. Supplement (0353-3735) 36 (2012), Suppl 2; 87-91

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
EGFR; FISH; gene amplification; hyperplastic glottic lesions; precancerous

Sažetak
The study searched for epidermal growth factor receptor (EGFR) gene amplification in hyperplastic glottis lesions. After classical pathohistological findings of hematoxylin-eosin (HE) slides and quantitative immunohistochemical (IHC) analysis, fluorescent in situ hybridization (FISH) was used on tissue microarrays of laryngeal hyperplastic tissue ranging from normal mucosa to abnormal and atypical hyperplastic lesions. FISH analysis of two atypical hyperplastic lesions discovered the amplification of EGFR gene while it was not found in simple and abnormal hyperplastic lesions. The results may indicate that EGFR gene amplifications could possibly correlate with the histopathologic picture. Tissue samples burdened with specific oncogen signatures like EGFR gene amplification could be detected in precancerous lesion. This might improve follow-up and treatment protocols of glottic lesions which are an everyday problem for ENT practitioners. Further research is mandatory to confirm our findings.

Izvorni jezik
Engleski



POVEZANOST RADA


Citiraj ovu publikaciju

Braut, Tamara; Kujundžić, Milodar; Vukelić, Jelena; Manestar, Dubravko; Krstulja, Mira; Starčević, Radan; Grahovac, Blaženka
Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia. // Collegium antropologicum. Supplement, 36 (2012), Suppl 2; 87-91 (podatak o recenziji nije dostupan, članak, znanstveni)
Braut, T., Kujundžić, M., Vukelić, J., Manestar, D., Krstulja, M., Starčević, R. & Grahovac, B. (2012) Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia.. Collegium antropologicum. Supplement, 36 (Suppl 2), 87-91.
@article{article, year = {2012}, pages = {87-91}, keywords = {EGFR, FISH, gene amplification, hyperplastic glottic lesions, precancerous}, journal = {Collegium antropologicum. Supplement}, volume = {36}, number = {Suppl 2}, issn = {0353-3735}, title = {Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia.}, keyword = {EGFR, FISH, gene amplification, hyperplastic glottic lesions, precancerous} }
@article{article, year = {2012}, pages = {87-91}, keywords = {EGFR, FISH, gene amplification, hyperplastic glottic lesions, precancerous}, journal = {Collegium antropologicum. Supplement}, volume = {36}, number = {Suppl 2}, issn = {0353-3735}, title = {Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia.}, keyword = {EGFR, FISH, gene amplification, hyperplastic glottic lesions, precancerous} }




Contrast
Increase Font
Decrease Font
Dyslexic Font