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Pregled bibliografske jedinice broj: 714559

Axon extension occurs independently of centrosomal microtubule nucleation


Stiess, Michael; Maghelli, Nicola; Kapitein, Lukas C.; Gomis-Rüth, Susana; Wilsch-Bräuninger, Michaela; Hoogenraad, Casper C.; Tolić-Nørrelykke, Iva M.; Bradke, Frank
Axon extension occurs independently of centrosomal microtubule nucleation // Science, 327 (2010), 5966; 704-707 doi:10.1126/science.1182179 (međunarodna recenzija, članak, znanstveni)


Naslov
Axon extension occurs independently of centrosomal microtubule nucleation

Autori
Stiess, Michael ; Maghelli, Nicola ; Kapitein, Lukas C. ; Gomis-Rüth, Susana ; Wilsch-Bräuninger, Michaela ; Hoogenraad, Casper C. ; Tolić-Nørrelykke, Iva M. ; Bradke, Frank

Izvornik
Science (0036-8075) 327 (2010), 5966; 704-707

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Centrosome; axon; neuron; microtubules; laser ablation

Sažetak
Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The centrosome is the classical site of microtubule nucleation and is thought to be essential for axon growth and neuronal differentiation--processes that require microtubule assembly. We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons. Axons still extended and regenerated through acentrosomal microtubule nucleation, and axons continued to grow after laser ablation of the centrosome in early neuronal development. Thus, decentralized microtubule assembly enables axon extension and regeneration, and, after axon initiation, acentrosomal microtubule nucleation arranges the cytoskeleton, which is the source of the sophisticated morphology of neurons.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Iva Marija Tolić, (260543)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


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