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Pregled bibliografske jedinice broj: 714381

Copy number variants and therapeutic response to antidepressant medication in major depressive disorder


Tansey, K.E.; Rucker, J.J.H.; Kavanagh, D.H.; Guipponi, M.; Perroud, N.; Bondolfi, G.; Domenici, E.; Evans, D.M.; Hausers, J.; Henigsberg, Neven et al.
Copy number variants and therapeutic response to antidepressant medication in major depressive disorder // Pharmacogenomics journal, 14 (2014), 4; 395-399 doi:10.1038/tpj.2013.51 (međunarodna recenzija, članak, znanstveni)


Naslov
Copy number variants and therapeutic response to antidepressant medication in major depressive disorder

Autori
Tansey, K.E. ; Rucker, J.J.H. ; Kavanagh, D.H. ; Guipponi, M. ; Perroud, N. ; Bondolfi, G. ; Domenici, E. ; Evans, D.M. ; Hausers, J. ; Henigsberg, Neven ; Jerman, Biserka ; Maier, W. ; Mors, O. ; O'Donovan, M. ; Peters, T. J. ; Placentino, A. ; Rietschel, M. ; Souery, D. ; Aitchison, K.J. ; Craig, I. ; Farmer, A. ; Wendland, J.R. ; Malafosse, A. ; Lewis, G. ; Kapur, S. ; McGuffin, P. ; Uher, R.

Izvornik
Pharmacogenomics journal (1470-269X) 14 (2014), 4; 395-399

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antidepressant; copy number variants; major depressive disorder; psychiatry; treatment response; 15q13.3

Sažetak
It would be beneficial to find genetic predictors of antidepressant response to help personalise treatment of major depressive disorder (MDD). Rare copy number variants (CNVs) have been implicated in several psychiatric disorders, including MDD, but their role in antidepressant response has yet to be investigated. CNV data were available for 1565 individuals with MDD from the NEWMEDS (Novel Methods leading to New Medications in Depression and Schizophrenia) consortium with prospective data on treatment outcome with either a serotonergic or noradrenergic antidepressant. No association was seen between the presence of CNV (rare or common), the overall number of CNVs or genomic CNV 'burden' and antidepressant response. Specific CNVs were nominally associated with antidepressant response, including 15q13.3 duplications and exonic NRXN1 deletions. These were associated with poor response to antidepressants. Overall burden of CNVs is unlikely to contribute to personalising antidepressant treatment. Specific CNVs associated with antidepressant treatment require replication and further study to confirm their role in the therapeutic action of antidepressant.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1880 - 1H-MRS promjene u predviđanju terapijskog odgovora, relapsa i povrata depresije (Neven Henigsberg, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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