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Histomorphology of the ectopicaly induced bone morphogenesis


Đudarić, Luka; Zoričić Cvek, Sanja; Cvijanović, Olga; Cuculić, Dražen; Pilipović, Kristina, Nikolić M, Fužinac Smojver A, Ćelić T, Bobinac D
Histomorphology of the ectopicaly induced bone morphogenesis // Revista Argentina de Anatomía Clínica / Biasutto, Susana (ur.).
General Paz, Córdoba, Argentina: Asociación Argentina de Anatomía Clínica, 2014. str. 108-108 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Histomorphology of the ectopicaly induced bone morphogenesis

Autori
Đudarić, Luka ; Zoričić Cvek, Sanja ; Cvijanović, Olga ; Cuculić, Dražen ; Pilipović, Kristina, Nikolić M, Fužinac Smojver A, Ćelić T, Bobinac D

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Revista Argentina de Anatomía Clínica / Biasutto, Susana - General Paz, Córdoba, Argentina : Asociación Argentina de Anatomía Clínica, 2014, 108-108

Skup
6th International Symposium of Clinical and Applied Anatomy

Mjesto i datum
Rijeka - Krk, Hrvatska, 26-29.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Histomorphology; ectopicaly induced bone morphogenesis

Sažetak
Aim: Investigate a dynamics of histogenetic processes of the ectopis osteogenesis. Materials and methods: Demineralized bone matrix implants were implanted subcutaneously pectoral region in rats. Animals were sacrificed after 5, 7, 14, 21 and 30 days of implantation. Hemalun-eosin, toluidine blue and Goldner trichrome staining were obtained. Results: At the 5th day of the implantation, a firm connective fibrous membrane on the surface of the implants was detected. Surface of the demineralized bone particles within the implant is subjected to multinuclear cells degradation, observed as lacunae and fissures. In the implants at the 7th day of the experimental protocol, similar morphological features to those of the 5th day were characterized by: thick fibrous membrane at the surface, high cellular infiltration between bone particles, numerous blood vessels and increased resorption. At the 14th day the first signs of the induced chondrogenesis are seen. Chondrocytic nests, consisted of hypertrophic chondrocytes, surrounded with the small amount of the metachromatic extracellular matrix are situated in between the bone particles. Also, cellular infiltration, bone particle degradation and blood vessels penetration are seen. At the day 21, some cartilage nests are degradated. Newly formed bone trabeculae, built of immature woven bone tissue are seen on the surface of the implant. Between bone particles, three- dimensional network of the bridging bone trabeculae is seen. At the 30th day of the experimental procedure for complete degradation of the implants is present. Conclusion: Histomorphological changes in implants correspond with process of endochondral and intramembranous ossification.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Sažetak ovog kongresnog priopćenja objavljen je u knjizi sažetaka i časopisu, te je u ovoj bibliografiji naveden u dvije rubrike (1. Sažeci u zbornicima skupova i 2. Kongresno priopćenje (sažeci) u ostalim časopisima).



POVEZANOST RADA


Projekt / tema
062-0000000-3559 - Uloga koštanih morfogenih proteina i inhibitora u nastanku osteofita čovjeka (Sanja Zoričić Cvek, )

Ustanove
Medicinski fakultet, Rijeka