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izvor podataka: crosbi

BMPs and their antagonists in development and growth of human knee joint osteophytes (CROSBI ID 613782)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Zoričić Cvek, Sanja ; Đudarić, Luka ; , Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina BMPs and their antagonists in development and growth of human knee joint osteophytes // 6th International Symposium of Clinical and Applied Anatomy : abstracts ; u: Revista Argentina de Anatomía Clínica 6 (2014) (2) / Biasutto, Susana (ur.). Cordoba: Asociación Argentina de Anatomía Clínica, 2014. str. 134-135

Podaci o odgovornosti

Zoričić Cvek, Sanja ; Đudarić, Luka ; , Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina

engleski

BMPs and their antagonists in development and growth of human knee joint osteophytes

The osteophytes are bone spurs overgrowing the edge of the articular cartilage during the course of osteoarthritis (OA). Although the cellular mechanism of their development and growth is revealed and resemblin normal bone development, there is still debate concerning molecular mechanism of their growth. Since the role of bone morphogenetic proteins family members (BMPs) in bone development is well established and documented, the members of the BMPs as an important member of the local grpwth factor network and their extracellular inhibitors were recognized as an important factors that could modulate, even cease development and growth of osteophytes. The aim of our study was to analyse expression and localization of the most potent osteoinductive BMP-2, -4 and -7, and their extracellular inhibitors gremlin, chordin, follisatin and noggin. The study was performed on tissue collection of 25 osteophytes collected during total knee joint replacement surgery due to severe OA, and on 10 samples of normal knee joint tissues from individuals undergoing autopsy. The expression of molecular factors was analysed using immunohistochemistry and Western blot analysis. Our result demonstrate the significant differences in BMPs and their antagonists expression between normal and OA affected joint tissue and suggest the potent role of these molecular factors in pathogenesis and / or mechanism of growth and development of human knee joint osteophytes.

BMP; BMP antagonists; osteophyte

Sažetak ovog kongresnog priopćenja objavljen je u Knjizi sažetaka ; Zoričić Cvek, Sanja (ur.) ; Rijeka, 2014 ; str. 14-14.

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Podaci o prilogu

134-135.

2014.

objavljeno

Podaci o matičnoj publikaciji

6th International Symposium of Clinical and Applied Anatomy : abstracts ; u: Revista Argentina de Anatomía Clínica 6 (2014) (2)

Biasutto, Susana

Cordoba: Asociación Argentina de Anatomía Clínica

1850-8023

Podaci o skupu

International Symposium of Clinical and Applied Anatomy (6 ; 2014)

predavanje

26.06.2014-29.06.2014

Krk, Hrvatska; Rijeka, Hrvatska

Povezanost rada

Temeljne medicinske znanosti