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izvor podataka: crosbi

Changes in IgG and total plasma protein glycomes in acute systemic inflammation (CROSBI ID 208496)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Novokmet, Mislav ; Lukić, Edita ; Vučković, Frano ; Ðurić, Željko ; Keser, Toma ; Rajšl, Katarina ; Remondini, Daniel ; Castellani, Gastone ; Gašparović, Hrvoje ; Gornik, Olga et al. Changes in IgG and total plasma protein glycomes in acute systemic inflammation // Scientific reports, 4 (2014), 4347-1-4347-. doi: 10.1038/srep04347

Podaci o odgovornosti

Novokmet, Mislav ; Lukić, Edita ; Vučković, Frano ; Ðurić, Željko ; Keser, Toma ; Rajšl, Katarina ; Remondini, Daniel ; Castellani, Gastone ; Gašparović, Hrvoje ; Gornik, Olga ; Lauc, Gordan

engleski

Changes in IgG and total plasma protein glycomes in acute systemic inflammation

Recovery after cardiac surgery is a complex process that has to compensate for both individual variability and extensive tissue damage in the context of systemic inflammation. Protein glycosylation is essential in many steps of the inflammatory cascade, but due to technological limitations the role of individual variation in glycosylation in systemic inflammation has not been addressed until now. We analysed composition of the total plasma and IgG N-glycomes in 107 patients undergoing cardiac surgery. In nearly all individuals plasma N-glycome underwent the same pattern of changes in the first 72 h, revealing a general mechanism of glycosylation changes. To the contrary, changes in the IgG glycome were very individualized. Bi-clustering analysis revealed the existence of four distinct patterns of changes. One of them, characterized by a rapid increase in galactosylated glycoforms, was associated with nearly double mortality risk measured by EuroSCORE II. Our results indicate that individual variation in IgG glycosylation changes during acute systemic inflammation associates with increased mortality risk and indicates new avenues for the development of personalized diagnostic and therapeutic approach.

inflammation ; IgG ; plasma ; glycans

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Podaci o izdanju

4

2014.

4347-1-4347-

objavljeno

2045-2322

10.1038/srep04347

Povezanost rada

Biologija

Poveznice
Indeksiranost