Napredna pretraga

Pregled bibliografske jedinice broj: 712996

Female headstart in resistance to hyperoxia-induced oxidative stress


Šarić, Ana; Sobočanec, Sandra; Mačak-Šafranko, Željka; Popović-Hadžija, Marijana; Aralica, Gorana; Korolija, Marina; Kušić, Borka; Balog, Tihomir
Female headstart in resistance to hyperoxia-induced oxidative stress // Acta biochimica Polonica, 61 (2014), 4; 801-807 (međunarodna recenzija, članak, znanstveni)


Naslov
Female headstart in resistance to hyperoxia-induced oxidative stress

Autori
Šarić, Ana ; Sobočanec, Sandra ; Mačak-Šafranko, Željka ; Popović-Hadžija, Marijana ; Aralica, Gorana ; Korolija, Marina ; Kušić, Borka ; Balog, Tihomir

Izvornik
Acta biochimica Polonica (0001-527X) 61 (2014), 4; 801-807

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hyperoxia; oxidative stress; ageing; resistance

Sažetak
Increased oxygen concentration (hyperoxia) induces oxidative damage of tissues and organs. Oxygen toxicity in hyperoxia is controlled by factors such as sex, age, tissue, strain and hormones. In most species females show lower incidence of some age-related pathologies linked with oxidative stress, which has been attributed to a beneficial effect of ovarian hormones. In this study we found that hyperoxia induced hepatic oxidative damage exclusively in male CBA/H mice, followed by their decreased survival. Histopathological examination revealed that the observed differences in survival were not the consequence of acute lung injury induced by hyperoxia. Next, we observed that an increased Sirt1 protein level in hyperoxia-exposed female CBA/H mice correlated with their lower PPAR-γ and higher eNOS and Sod2 protein levels. In males, higher PPAR-γ and lower Sod2 protein levels were associated with unchanged Sirt1 expression. Although these results are of a correlative nature only, they clearly show that females show better survival, increased resistance to hyperoxia and have generally more efficient defense systems, which suggests that their headstart in resistance to hyperoxia could be a consequence of the beneficial effect of ovarian hormones.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )
098-0982464-2460 - Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša (Mirko Hadžija, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE