engleski

Firing patterns of muscle sympathetic neurons during apnea in chronic heart failure patients and healthy controls

In the present study we investigated the influence of end-expiratory breathing cessation on firing activity of muscle sympathetic fibers in 6 stable chronic heart failure (CHF) patients and in 6 healthy age and gender matched controls. Integrated multi-unit bursts, as well as action potentials (APs), were identified from multi-unit muscle sympathetic nerve activity (MSNA) recordings during baseline and during functional residual capacity (FRC) apnea. Compared with controls, CHF patients had higher burst frequency and AP firing frequency (P<0.05) at baseline. FRC apnea caused an increase in the number of APs per multi-unit sympathetic burst, in the AP frequency (P<0.05) and in the number of active clusters per multi-unit sympathetic burst in both groups (controls P<0.06, CHF group P=0.1). The data suggest a comparable pattern of sympathetic activation associated with breath hold in healthy middle-aged individuals and in stable CHF patients. Thus, recruitment patterns for this stress are not affected by CHF despite their elevated sympathetic state.

muscle sympathetic nerve activity; chronic heart failure

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