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Pregled bibliografske jedinice broj: 712719

Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development


Sekelj, Sandra; Dekaris, Iva; Balog, Tihomir; Mahovne, Ivana; Krstonijević-Kondža, Edita; Janjetović, Željka; Arar-Vuković, Željka; Arić, Ivana
Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development // Current eye research, 40 (2014), 4; 407-414 doi:10.3109/02713683.2014.925935 (međunarodna recenzija, članak, znanstveni)


Naslov
Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development

Autori
Sekelj, Sandra ; Dekaris, Iva ; Balog, Tihomir ; Mahovne, Ivana ; Krstonijević-Kondža, Edita ; Janjetović, Željka ; Arar-Vuković, Željka ; Arić, Ivana

Izvornik
Current eye research (0271-3683) 40 (2014), 4; 407-414

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ELISA; graft rejection; immunohistochemistry; penetrating keratoplasty; vascular endothelial growth factor

Sažetak
Purpose was to evaluate whether the vascular endothelial growth factor A (VEGF-A) in the recipient cornea measured at the time of penetrating keratoplasty (PK) can act as a prognostic factor for corneal graft reaction development. The study included 25 eyes (of 25 patients) scheduled for PK. According to preoperative clinical finding, patients were divided into three groups: inflammatory with neovascularization (n = 11) ; inflammatory without neovascularization (n = 7) ; and non-inflammatory (n = 7). One half of the recipient cornea was analyzed for the levels of VEGF-A protein using a commercial enzyme-linked immunosorbent assay ; the other half was analyzed to determine the loci of VEGF-A production by immunohistochemistry. The frequencies of corneal graft reaction and rejection were recorded, together with the improvement of visual acuity. Twenty-five donor corneas obtained from cadaver eyes represented the control group (n = 25). There was a statistically significant difference in the levels of VEGF-A protein between the recipient corneal buttons obtained from eyes with inflammatory changes and neovascularization, and those from the non-inflammatory group and controls (p < 0.01). The level of VEGF-A was 287.74 pg/ml (standard deviation [SD] =  129.181) in the inflammatory with corneal neovascularization group, 227.64 pg/ml (SD =  85.590) in the inflammatory without neovascularization group, 115.37 pg/ml (SD =  105.93) in the non-inflammatory group, and 142.28 pg/ml (SD = 93.081) in the control group. Graft reaction/rejection rate was 54.5%/45.5% in the inflammatory with neovascularization group, 14.3%/0% in the inflammatory without neovascularization group, and 14.3%/14.3% in non-inflammatory group. Patients who developed clinical signs of graft reaction during the postoperative follow-up had a significantly higher level of VEGF-A (307.4  pg/ml, SD = 100.058) compared with those without any signs of graft reaction (182.8  pg/ml, SD = 124.987). Our results suggest that both graft reaction and final graft rejection occur more often in patients with increased levels of VEGF-A in a recipient cornea at the time of PK.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Opća bolnica "Dr. Josip Benčević"

Profili:

Avatar Url Iva Dekaris (autor)

Avatar Url Tihomir Balog (autor)

Avatar Url Sandra Sekelj (autor)

Citiraj ovu publikaciju

Sekelj, Sandra; Dekaris, Iva; Balog, Tihomir; Mahovne, Ivana; Krstonijević-Kondža, Edita; Janjetović, Željka; Arar-Vuković, Željka; Arić, Ivana
Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development // Current eye research, 40 (2014), 4; 407-414 doi:10.3109/02713683.2014.925935 (međunarodna recenzija, članak, znanstveni)
Sekelj, S., Dekaris, I., Balog, T., Mahovne, I., Krstonijević-Kondža, E., Janjetović, Ž., Arar-Vuković, Ž. & Arić, I. (2014) Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development. Current eye research, 40 (4), 407-414 doi:10.3109/02713683.2014.925935.
@article{article, year = {2014}, pages = {407-414}, DOI = {10.3109/02713683.2014.925935}, keywords = {ELISA, graft rejection, immunohistochemistry, penetrating keratoplasty, vascular endothelial growth factor}, journal = {Current eye research}, doi = {10.3109/02713683.2014.925935}, volume = {40}, number = {4}, issn = {0271-3683}, title = {Vascular Endothelial Growth Factor in a Recipient Cornea Acts as a Prognostic Factor for Corneal Graft Reaction Development}, keyword = {ELISA, graft rejection, immunohistochemistry, penetrating keratoplasty, vascular endothelial growth factor} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE
  • 098-0000000-0222, 098-0982464-1647


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