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Pregled bibliografske jedinice broj: 712558

Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride


Pinto, Victor H.A.; Da-Silva, Dayse Carvalho; Santos, Jonas L.M.S.; Weitner, Tin; Fonseca, Maria Gardênnia; Yoshida, Maria Irene; Idemori, Ynara M.; Batinic-Haberle, Ines; Rebouças, Julio S.;
Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride // Journal of pharmaceutical and biomedical analysis, 73 (2013), 29-34 doi:10.1016/j.jpba.2012.03.033 (međunarodna recenzija, članak, znanstveni)


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Naslov
Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride

Autori
Pinto, Victor H.A. ; Da-Silva, Dayse Carvalho ; Santos, Jonas L.M.S. ; Weitner, Tin ; Fonseca, Maria Gardênnia ; Yoshida, Maria Irene ; Idemori, Ynara M. ; Batinic-Haberle, Ines ; Rebouças, Julio S. ;

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 73 (2013); 29-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
porphyrin; thermal analysis; antioxidant; SOD mimic; dealkylation

Sažetak
Cationic Mn porphyrins are among the most potent catalytic antioxidants and/or cellular redox modulators. Mn(III) meso-tetrakis(N- ethylpyridinium-2-yl)porphyrin chloride (MnTE-2- PyPCl5) is the Mn porphyrin most studied in vivo and has successfully rescued animal models of a variety of oxidative stress-related diseases. The stability of an authentic MnTE-2-PyPCl5 sample was investigated hereon by thermogravimetric, derivative thermogravimetric, and differential thermal analyses (TG/DTG/DTA), under dynamic air, followed by studies at selected temperatures to evaluate the decomposition path and appropriate conditions for storage and handling of these materials. All residues were analyzed by thin- layer chromatography (TLC) and UV–vis spectroscopy. Three thermal processes were observed by TG/DTG. The first event (endothermic) corresponded to dehydration, and did not alter the MnTE-2-PyPCl5 moiety. The second event (endothermic) corresponded to the loss of EtCl (dealkylation), which was characterized by gas chromatography–mass spectrometry. The residue at 279 °C had UV–vis and TLC data consistent with those of the authentic, completely dealkylated analog, MnT-2-PyPCl. The final, multi-step event corresponded to the loss of the remaining organic matter to yield Mn3O4 which was characterized by IR spectroscopy. Isothermal treatment at 188 °C under static air for 3 h yielded a mixture of partially dealkylated MnPs and traces of the free- base, dealkylated ligand, H2T-2-PyP, which reveals that dealkylation is accompanied by thermal demetallation under static air conditions. Dealkylation was not observed if the sample was heated as a solid or in aqueous solution up to ∼100 °C. Whereas moderate heating changes sample composition by loss of H2O, the dehydrated sample is indistinguishable from the original sample upon dissolution in water, which indicates that catalytic activity (on Mn basis) remains unaltered. Evidently, dealkylation at high temperature compromises sample activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Rad je prezentiran na skupu 23rd International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2011), održanom od 09-12.10.2011.g., João Pessoa, Brazil.



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ines Batinić-Haberle (autor)

Avatar Url Tin Weitner (autor)

Citiraj ovu publikaciju

Pinto, Victor H.A.; Da-Silva, Dayse Carvalho; Santos, Jonas L.M.S.; Weitner, Tin; Fonseca, Maria Gardênnia; Yoshida, Maria Irene; Idemori, Ynara M.; Batinic-Haberle, Ines; Rebouças, Julio S.;
Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride // Journal of pharmaceutical and biomedical analysis, 73 (2013), 29-34 doi:10.1016/j.jpba.2012.03.033 (međunarodna recenzija, članak, znanstveni)
Pinto, V., Da-Silva, D., Santos, J., Weitner, T., Fonseca, M., Yoshida, M., Idemori, Y., Batinic-Haberle, I., Rebouças, J. & (2013) Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride. Journal of pharmaceutical and biomedical analysis, 73, 29-34 doi:10.1016/j.jpba.2012.03.033.
@article{article, year = {2013}, pages = {29-34}, DOI = {10.1016/j.jpba.2012.03.033}, keywords = {porphyrin, thermal analysis, antioxidant, SOD mimic, dealkylation}, journal = {Journal of pharmaceutical and biomedical analysis}, doi = {10.1016/j.jpba.2012.03.033}, volume = {73}, issn = {0731-7085}, title = {Thermal Stability of the Prototypical Mn porphyrin-based Superoxide Dismutase Mimic and Potent Oxidative-Stress Redox Modulator Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride}, keyword = {porphyrin, thermal analysis, antioxidant, SOD mimic, dealkylation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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