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HPLC–DAD–FLD determination of veterinary pharmaceuticals in pharmaceutical industry wastewater with precolumn derivatization using fluorescamine (CROSBI ID 208036)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ašperger, Danijela ; Tišler, Vesna ; Zrnčić, Mirta ; Mutavdžić Pavlović, Dragana ; Babić, Sandra ; Horvat, Alka J. M. ; Kaštelan-Macan, Marija HPLC–DAD–FLD determination of veterinary pharmaceuticals in pharmaceutical industry wastewater with precolumn derivatization using fluorescamine // Chromatographia, 77 (2014), 15-16; 1059-1066. doi: 10.1007/s10337-014-2685-x

Podaci o odgovornosti

Ašperger, Danijela ; Tišler, Vesna ; Zrnčić, Mirta ; Mutavdžić Pavlović, Dragana ; Babić, Sandra ; Horvat, Alka J. M. ; Kaštelan-Macan, Marija

engleski

HPLC–DAD–FLD determination of veterinary pharmaceuticals in pharmaceutical industry wastewater with precolumn derivatization using fluorescamine

A simple and robust method suitable for routine analysis of pharmaceuticals from different classes in pharmaceutical industry wastewater samples is presented. Seven veterinary pharmaceuticals (antibiotics and anesthetic) were simultaneously isolated from a highly complex wastewater matrix. Target compounds were three sulfonamide antibiotics (sulfaguanidine, sulfadiazine, and sulfamethazine), three fluoroquinolone antibiotics (ciprofloxacin, enrofloxacin, norfloxacin), and one anesthetic, procaine. The investigated compounds were simultaneously pre-concentrated and cleaned up by solid-phase extraction using Strata-X extraction cartridges. The analysis was performed using liquid chromatography (LC) with diode array and fluorescence detectors connected in series to the chromatographic system. LC separation was performed on a C18 modified column (Phenomenex) with a gradient elution of mobile phase (0.1 % acetic acid in water and 0.1 % acetic acid in acetonitrile) in 25 min at 30 °C. Recoveries ranged from 86.9 to 110 % with relative standard deviations below 10.1 %. Method limits of quantification were in the range of 0.005–0.1 μg L−1 depending on the fluorescence intensity after precolumn derivatization by fluorescamine.

High-performance liquid chromatography ; Fluorescence detection ; Derivatization ; Fluorescamine ; Pharmaceuticals ; Wastewater

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Podaci o izdanju

77 (15-16)

2014.

1059-1066

objavljeno

0009-5893

1612-1112

10.1007/s10337-014-2685-x

Povezanost rada

Kemija

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