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Pregled bibliografske jedinice broj: 711035

Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice


Martinić, Roko; Šošić, Hrvoje; Turčić, Petra; Konjevoda, Paško; Fučić, Aleksandra; Stojković, Ranko; Aralica, Gorana; Gabričević, Mario; Weitner, Tin; Štambuk, Nikola
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice // Molecules, 19 (2014), 8; 11833-11845 doi:10.3390/molecules190811833 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 711035 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice

Autori
Martinić, Roko ; Šošić, Hrvoje ; Turčić, Petra ; Konjevoda, Paško ; Fučić, Aleksandra ; Stojković, Ranko ; Aralica, Gorana ; Gabričević, Mario ; Weitner, Tin ; Štambuk, Nikola

Izvornik
Molecules (1420-3049) 19 (2014), 8; 11833-11845

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
met-enkephalin; hepatoprotection; genotoxicity; antisense peptide; binding; spectroscopy

Sažetak
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis. Consequently, we evaluated the potential hepatoprotective effects of this endogenous opioid pentapeptide in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice. Met-enkephalin exhibited strong hepatoprotective effects in a dose of 7.5 mg/kg, which corresponds to the protective dose reported for several different animal disease models. In this group plasma alanine aminotransferase and aspartate aminotransferase enzyme activities, as well as liver necrosis score were significantly reduced in comparison to control animals treated with physiological saline (p > 0.01). The specificity of the peptide hepatoprotection was investigated from the standpoint of the receptor and peptide blockade. It was concluded that Met-enkephalin effects on the liver were mediated via δ and ζ opioid receptors. Genotoxic testing of Met- enkephalin confirmed the safety of the peptide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
098-0982929-2524 - Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka (Nikola Štambuk, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC Split,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Martinić, Roko; Šošić, Hrvoje; Turčić, Petra; Konjevoda, Paško; Fučić, Aleksandra; Stojković, Ranko; Aralica, Gorana; Gabričević, Mario; Weitner, Tin; Štambuk, Nikola
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice // Molecules, 19 (2014), 8; 11833-11845 doi:10.3390/molecules190811833 (međunarodna recenzija, članak, znanstveni)
Martinić, R., Šošić, H., Turčić, P., Konjevoda, P., Fučić, A., Stojković, R., Aralica, G., Gabričević, M., Weitner, T. & Štambuk, N. (2014) Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice. Molecules, 19 (8), 11833-11845 doi:10.3390/molecules190811833.
@article{article, year = {2014}, pages = {11833-11845}, DOI = {10.3390/molecules190811833}, keywords = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy}, journal = {Molecules}, doi = {10.3390/molecules190811833}, volume = {19}, number = {8}, issn = {1420-3049}, title = {Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice}, keyword = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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