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Peptidomimetics derived from ferrocene mono- and diamines


Kovačević, Monika; Čakić Semenčić, Mojca; Kodrin, Ivan; Roca, Sunčica; Meden, Anton; Barišić, Lidija
Peptidomimetics derived from ferrocene mono- and diamines // 7th International Symposium on Bioorganometallic Chemistry / Keppler, Bernhard ; Hartinger, Christian ; Kandioller, Wolfgang (ur.).
Wien, 2014. str. P02-P02 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Peptidomimetics derived from ferrocene mono- and diamines

Autori
Kovačević, Monika ; Čakić Semenčić, Mojca ; Kodrin, Ivan ; Roca, Sunčica ; Meden, Anton ; Barišić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th International Symposium on Bioorganometallic Chemistry / Keppler, Bernhard ; Hartinger, Christian ; Kandioller, Wolfgang - Wien, 2014, P02-P02

Skup
7th International Symposium on Bioorganometallic Chemistry

Mjesto i datum
Beč, Austrija, 22.-25.07.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ferrocene ; Proline ; Peptidomimetic ; Intramolecular hydrogen bond ; Conformational analysis

Sažetak
Ferrocene-peptide conjugates present useful and efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. As opposed to well-documented peptides derived from ferrocene-1, 1’-dicarboxylic acid (Fcda) and 1’-aminoferrocene-1-carboxylic acid (Fca) [1], only two representatives of peptides I derived from ferrocene-1, 1’-diamine were reported [2]. We have established a facile and efficient synthetic route for preparation of peptides I which does not include unstable Fcda synthon. Recently, we have showed that introduction of minimum-sized peptide chain on aminoferrocene II led to the formation of a β-turn-like structure originating from intrachain hydrogen- bonding. Herein, we present the synthesis of peptides I and II bearing homo- and heterochiral Ala-Pro sequences followed by extensive studies of their conformational preferences in solution as well as in solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
058-1191344-3122 - Metalocenski biokonjugati, heterocikli i makromolekule (Veronika Kovač, )
119-1191342-1339 - Molekulsko modeliranje strukture i reaktivnosti organskih spojeva (Zlatko Mihalić, )

Ustanove
Prehrambeno-biotehnološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Kovačević, Monika; Čakić Semenčić, Mojca; Kodrin, Ivan; Roca, Sunčica; Meden, Anton; Barišić, Lidija
Peptidomimetics derived from ferrocene mono- and diamines // 7th International Symposium on Bioorganometallic Chemistry / Keppler, Bernhard ; Hartinger, Christian ; Kandioller, Wolfgang (ur.).
Wien, 2014. str. P02-P02 (poster, međunarodna recenzija, sažetak, znanstveni)
Kovačević, M., Čakić Semenčić, M., Kodrin, I., Roca, S., Meden, A. & Barišić, L. (2014) Peptidomimetics derived from ferrocene mono- and diamines. U: Keppler, B., Hartinger, C. & Kandioller, W. (ur.)7th International Symposium on Bioorganometallic Chemistry.
@article{article, year = {2014}, pages = {P02-P02}, keywords = {Ferrocene, Proline, Peptidomimetic, Intramolecular hydrogen bond, Conformational analysis}, title = {Peptidomimetics derived from ferrocene mono- and diamines}, keyword = {Ferrocene, Proline, Peptidomimetic, Intramolecular hydrogen bond, Conformational analysis}, publisherplace = {Be\v{c}, Austrija} }