engleski

Dialysis and Renal Transplantation in HIV-Infected Patients : a European Survey

Objectives: To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients. Methods: Cross- sectional multicenter survey of EuroSIDA clinics during 2008. Results: Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS ; 91% were receiving antiretrovirals ; and 88% had undetectable viral load. Median CD4(+) T-cell count was 341 cells per cubic millimetre ; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality ; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%). Conclusions: This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two- thirds of patients were excluded from RT for non HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.

Adult; CD4 Lymphocyte Count; Cross-Sectional Studies; Europe; Female; HIV Infections/complications/ epidemiology; Hepatitis Viruses; Hepatitis; Viral; Human/complications/ epidemiology; Humans; Kidney Failure; Chronic/complications/ epidemiology; Kidney Transplantation; Male; Middle Aged; Renal Dialysis

Group Authors: EuroSIDA.