engleski

Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe

Background: Little is known about the incidence and risk factors for serious non-AIDS-defining events. Methods: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated ; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. Results: Among 12, 844 patients, 1058 were diagnosed with a non- AIDS event [incidence 1.77 per 100 person-years of follow-up ; 95% confidence interval (CI): 1.66 to 1.87] ; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses ; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14 ; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72 ; 95% CI: 5.61 to 8.05). Conclusions: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV- infected persons is an important but unmet research need.

Acquired Immunodeficiency Syndrome/ complications/mortality; Age Factors; Antiretroviral Therapy; Highly Active/mortality; CD4 Lymphocyte Count; Epidemiology/statistics & numerical data; Europe/epidemiology; Female; Humans; Incidence; Kaplan-Meier Estimate; Male; Mortality; Poisson Distribution; Proportional Hazards Models; Risk Factors

Group Authors: EuroSIDA.