CD44 correlates with MMP-9 in prostate carcinoma (CROSBI ID 613306)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Đorđević, Gordana ; Štifter, Sanja ; Hadžisejdić, Ita ; Mozetič, Vladimir ; Oguić, Romano ; Mustać, Elvira
engleski
CD44 correlates with MMP-9 in prostate carcinoma
Objectives: CD 44 is the adhesion molecule shown to be a useful prognostic marker of aggressive prostate cancer. Also, CD44s accumulates metalloproteinase-9 (MMP-9) on the cell membrane which allows angiogenesis and invasion. The aim of this study was to investigate the expression of CD44 in prostate cancer specimens obtained by prostatectomy and to correlate it with MMP-9 expression. Methods:Tissue microarrays (TMA) of 120 archival, formalin fixed paraffin embedded prostate carcinoma were immunohistochemically evaluated for CD44s and MMP-9 expression Results: Median CD44 expression was 52.1713 ( SD±48.6701) with non significant correlation with clinicopathological parameters, stage, margin status or reccurence free survival. CD44 molecule shows loss of expression in tumor cells, discontinuous membrane staining and focal irregular distribution in tumors with higher Gleason score. CD44 and MMP9 showed inverse correlation (p=0.0198). Conclusion: Our results showed loss of expression of CD44 in poorly differentiated tumors, while correlation with MMP9 needs further evaluation.
CD44; prostate cancer; prognosis
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Podaci o prilogu
342-x.
2013.
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objavljeno
Podaci o matičnoj publikaciji
Virchows archiv
Springer
0945-6317
Podaci o skupu
25th European Congress of Pathology
poster
31.08.2013-04.09.2013
Lisabon, Portugal
Povezanost rada
Kliničke medicinske znanosti