The Use of Hyperthermia in Cancer Therapy (CROSBI ID 481345)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Radačić, Marko ; Stojković, Ranko ; Radačić, Matea
engleski
The Use of Hyperthermia in Cancer Therapy
Hyperthermia as a treatment modality for cancer has been recommended by Hyppocrates (400 yrs B.C) . Hyperthermia as a modern treatment tool, in cancer chemotherapy, entered in the beginning of the last century. Hyperthermia may be defined as a therapy in which tissue temperature is raised between 41şC and 45şC in order to cure cancer. It can be used locally, regionally or as a total body hyperthermia. Its dose depends of the way of application and duration of the time. Hyperthermia as a single treatment rarely can cure tumour and for that reason is mainly used in combined therapeutic protocols, i.e. in combination with radiation and/or chemotherapy. Hyperthermia induces structural and functional alterations in all cell elements: plasma membranes, cytoskeleton, cytosol and nucleus. It alters membrane permeability and transport functions of the plasma membrane. Hyperthermic killing may be associated with the effects on the protein components on the plasma membrane and with the increased drug level into the cell during heat. The severity and type of all heat-induced changes depend on the temperature, length of the treatment and on the cell type treated. Hyperthermia has two biological effects ; direct cytotoxicity and radio-chemo-sensitisation. Due to its radiosenzitization effect it is quite often used as adjuvant to radiation and/or to chemotherapy in the treatment of local and regional tumours and gives very good therapeutic results
hyperthermia; cancer therapy; mice
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Podaci o prilogu
812-815-x.
2001.
objavljeno
Podaci o matičnoj publikaciji
IFMBE Proceedings
Ratko, Magjarević ; Stanko, Tonković ; Vedran, Bilas ; Igor, Lackov
Zagreb: Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku ; Fakultet elektrotehnike i računarstva Sveučilišta u Zagrebu
Podaci o skupu
Medicon 2001. IX Mediterranean Conference on Medical and Biological Engineering and Computing
predavanje
12.06.2001-15.06.2001
Pula, Hrvatska