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The Use of Hyperthermia in Cancer Therapy


Radačić, Marko; Stojković, Ranko; Radačić, Matea
The Use of Hyperthermia in Cancer Therapy // IFMBE Proceedings / Ratko, Magjarević ; Stanko, Tonković ; Vedran, Bilas ; Igor, Lackov (ur.).
Zagreb: FER, CROMBES, 2001. str. 812-815 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
The Use of Hyperthermia in Cancer Therapy

Autori
Radačić, Marko ; Stojković, Ranko ; Radačić, Matea

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
IFMBE Proceedings / Ratko, Magjarević ; Stanko, Tonković ; Vedran, Bilas ; Igor, Lackov - Zagreb : FER, CROMBES, 2001, 812-815

Skup
Medicon 2001. IX Mediterranean Conference on Medical and Biological Engineering and Computing

Mjesto i datum
Pula, Hrvatska, 12-15.06.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hyperthermia; cancer therapy; mice

Sažetak
Hyperthermia as a treatment modality for cancer has been recommended by Hyppocrates (400 yrs B.C) . Hyperthermia as a modern treatment tool, in cancer chemotherapy, entered in the beginning of the last century. Hyperthermia may be defined as a therapy in which tissue temperature is raised between 41şC and 45şC in order to cure cancer. It can be used locally, regionally or as a total body hyperthermia. Its dose depends of the way of application and duration of the time. Hyperthermia as a single treatment rarely can cure tumour and for that reason is mainly used in combined therapeutic protocols, i.e. in combination with radiation and/or chemotherapy. Hyperthermia induces structural and functional alterations in all cell elements: plasma membranes, cytoskeleton, cytosol and nucleus. It alters membrane permeability and transport functions of the plasma membrane. Hyperthermic killing may be associated with the effects on the protein components on the plasma membrane and with the increased drug level into the cell during heat. The severity and type of all heat-induced changes depend on the temperature, length of the treatment and on the cell type treated. Hyperthermia has two biological effects ; direct cytotoxicity and radio-chemo-sensitisation. Due to its radiosenzitization effect it is quite often used as adjuvant to radiation and/or to chemotherapy in the treatment of local and regional tumours and gives very good therapeutic results

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
00981111

Ustanove
Institut "Ruđer Bošković", Zagreb