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The Use of Hyperthermia in Cancer Therapy (CROSBI ID 481345)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Radačić, Marko ; Stojković, Ranko ; Radačić, Matea The Use of Hyperthermia in Cancer Therapy // IFMBE Proceedings / Ratko, Magjarević ; Stanko, Tonković ; Vedran, Bilas et al. (ur.). Zagreb: Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku ; Fakultet elektrotehnike i računarstva Sveučilišta u Zagrebu, 2001. str. 812-815-x

Podaci o odgovornosti

Radačić, Marko ; Stojković, Ranko ; Radačić, Matea

engleski

The Use of Hyperthermia in Cancer Therapy

Hyperthermia as a treatment modality for cancer has been recommended by Hyppocrates (400 yrs B.C) . Hyperthermia as a modern treatment tool, in cancer chemotherapy, entered in the beginning of the last century. Hyperthermia may be defined as a therapy in which tissue temperature is raised between 41şC and 45şC in order to cure cancer. It can be used locally, regionally or as a total body hyperthermia. Its dose depends of the way of application and duration of the time. Hyperthermia as a single treatment rarely can cure tumour and for that reason is mainly used in combined therapeutic protocols, i.e. in combination with radiation and/or chemotherapy. Hyperthermia induces structural and functional alterations in all cell elements: plasma membranes, cytoskeleton, cytosol and nucleus. It alters membrane permeability and transport functions of the plasma membrane. Hyperthermic killing may be associated with the effects on the protein components on the plasma membrane and with the increased drug level into the cell during heat. The severity and type of all heat-induced changes depend on the temperature, length of the treatment and on the cell type treated. Hyperthermia has two biological effects ; direct cytotoxicity and radio-chemo-sensitisation. Due to its radiosenzitization effect it is quite often used as adjuvant to radiation and/or to chemotherapy in the treatment of local and regional tumours and gives very good therapeutic results

hyperthermia; cancer therapy; mice

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Podaci o prilogu

812-815-x.

2001.

objavljeno

Podaci o matičnoj publikaciji

IFMBE Proceedings

Ratko, Magjarević ; Stanko, Tonković ; Vedran, Bilas ; Igor, Lackov

Zagreb: Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku ; Fakultet elektrotehnike i računarstva Sveučilišta u Zagrebu

Podaci o skupu

Medicon 2001. IX Mediterranean Conference on Medical and Biological Engineering and Computing

predavanje

12.06.2001-15.06.2001

Pula, Hrvatska

Povezanost rada

Biologija