γ-H2AX as a biomarker for DNA double-strand breaks in ecotoxicology (CROSBI ID 207711)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Gerić, Marko ; Gajski, Goran ; Garaj-Vrhovac, Vera
engleski
γ-H2AX as a biomarker for DNA double-strand breaks in ecotoxicology
The visualisation of DNA damage response proteins enables the indirect measurement of DNA damage. Soon after the occurrence of a DNA double-strand break (DSB), the formation of γ-H2AX histone variants is to be expected. This review is focused on the potential use of the γ-H2AX foci assay in assessing the genotoxicity of environmental contaminants including cytostatic pharmaceuticals, since standard methods may not be sensitive enough to detect the damaging effect of low environmental concentrations of such drugs. These compounds are constantly released into the environment, potentially representing a threat to water quality, aquatic organisms, and, ultimately, human health. Our review of the literature revealed that this method could be used in the biomonitoring and risk assessment of aquatic systems affected by wastewater from the production, usage, and disposal of cytostatic pharmaceuticals.
γ-H2AX foci assay; genotoxicity; double-strand breaks; cytostatic pharmaceuticals; environmental concentrations
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Podaci o izdanju
105
2014.
13-21
objavljeno
0147-6513
10.1016/j.ecoenv.2014.03.035