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Pregled bibliografske jedinice broj: 708538

Patterns of heterozygosity and inbreeding in Neandertals across Eurasia.


Kuhlwilm, M., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Pääbo, S., Castellano, S.
Patterns of heterozygosity and inbreeding in Neandertals across Eurasia. // Poster Abstracts SMBE 2014 / SMBE (ur.).
San Juan: SMBE, 2014. str. P-1070 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 708538 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Patterns of heterozygosity and inbreeding in Neandertals across Eurasia.

Autori
Kuhlwilm, M., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Pääbo, S., Castellano, S.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Poster Abstracts SMBE 2014 / SMBE - San Juan : SMBE, 2014, P-1070

Skup
Molecular Evolution: From Genome Technology to the History of Life

Mjesto i datum
San Juan, Puerto Rico., 8 -12.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Neandertals; DNA; Inbreeding; Eurasia

Sažetak
The high-coverage sequencing of a Neandertal and a Denisovan individual from the Altai Mountains in Siberia provided insights into the history and relationships of these archaic individuals to modern humans (Meyer et al. 2012 ; Prüfer et al. 2014). We used densely tiled oligonucleotide probes to capture 30 million bases of the human chromosome 21 from two Neandertal individuals from El Sidrón in Spain and Vindija in Croatia, and sequenced them to 12- and 34-fold, respectively. We compared the genotypes of these individuals to the same regions from the chromosomes 21 of a Neandertal and a Denisovan, as well as to 25 presentday humans from different populations around the world. Heterozygosities in the two Neandertals from Europe are similar to that of the Denisovan individual and about one third of the lowest heterozygosity seen in the present-day humans. Only the Altai Neandertal shows a lower heterozygosity. As described, the Altai Neandertal shows a large number of large regions of homozygosity that are the result of recent inbreeding. The two European Neandertals show fewer and smaller such regions of homozygosity that are still larger than what is seen in any of the present-day humans. These results suggest that the long-term population size of Neandertals across their geographic range was low, while only the Altai Neandertal shows an excess of long homozygous regions due to recent inbreeding.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Biologija



POVEZANOST RADA


Projekt / tema
101-2690680-2270 - Korelacija paleolitika mezolitika i neolitika kontinentalne i primorske Hrvatske (Dejana Brajković, )

Ustanove
Hrvatska akademija znanosti i umjetnosti

Profili:

Avatar Url Ivan Gušić (autor)

Avatar Url Željko Kućan (autor)

Avatar Url Pavao Rudan (autor)

Avatar Url Dejana Brajković (autor)

Citiraj ovu publikaciju

Kuhlwilm, M., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Pääbo, S., Castellano, S.
Patterns of heterozygosity and inbreeding in Neandertals across Eurasia. // Poster Abstracts SMBE 2014 / SMBE (ur.).
San Juan: SMBE, 2014. str. P-1070 (poster, međunarodna recenzija, sažetak, znanstveni)
Kuhlwilm, M., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Pääbo, S., Castellano, S. (2014) Patterns of heterozygosity and inbreeding in Neandertals across Eurasia.. U: SMBE (ur.)Poster Abstracts SMBE 2014.
@article{article, year = {2014}, pages = {P-1070-S 6}, keywords = {Neandertals, DNA, Inbreeding, Eurasia}, title = {Patterns of heterozygosity and inbreeding in Neandertals across Eurasia.}, keyword = {Neandertals, DNA, Inbreeding, Eurasia}, publisher = {SMBE}, publisherplace = {San Juan, Puerto Rico.} }