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Pregled bibliografske jedinice broj: 705969

Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men.


Golubić, Karlo; Šmalcelj, Anton; Sertić, Jadranka; Juričić, Ljiljana
Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men. // Croatian medical journal, 55 (2014), 1; 38-44 doi:10.3325/cmj.2014.55.38 (međunarodna recenzija, članak, znanstveni)


Naslov
Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men.

Autori
Golubić, Karlo ; Šmalcelj, Anton ; Sertić, Jadranka ; Juričić, Ljiljana

Izvornik
Croatian medical journal (0353-9504) 55 (2014), 1; 38-44

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Estrogen receptor 1 gene (TA)n polymorphism; atrial fibrillation

Sažetak
Aim was to determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men. We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome. Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n repeat number was associated with a significantly greater likelihood of AF (odds ratio 1.069 ; 95% confidence interval 1.024-1.116, P=0.002). Our results indicate that a greater number of (TA)n repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-1081875-2001 - Atrijska fibrilacija: od genoma do fenotipa i kliničke slike (Anton Šmalcelj, )

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Sveučilište u Zagrebu

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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