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Pregled bibliografske jedinice broj: 705876

Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide


Stražić, Dubravka; Benković, Tomislav; Gembarovski, Dubravka; Kontrec, Darko; Galić, Nives
Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide // International journal of mass spectrometry, 371 (2014), 54-64 doi:10.1016/j.ijms.2014.07.036 (međunarodna recenzija, članak, znanstveni)


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Naslov
Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide

Autori
Stražić, Dubravka ; Benković, Tomislav ; Gembarovski, Dubravka ; Kontrec, Darko ; Galić, Nives

Izvornik
International journal of mass spectrometry (1387-3806) 371 (2014); 54-64

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
electrospray mass spectrometry; hydrazones; structural isomers; tautomerism; fragmentation

Sažetak
Aroylhydrazones 1-13 derived from nicotinic acid hydrazide and differently substituted benzaldehyde or ketone (2-hydroxyacetophenone and 2-hydroxybenzophenone) were analyzed by ESI MS both in positive and negative ion mode. The influence of the solvent (acetonitrile, methanol, addition of formic acid, ammonium or sodium acetate) on signal intensities was investigated. A comprehensive study of fragmentation pathways of hydrazones using triple quadrupole and ion trap instruments is presented. Structural isomers of aroylhydrazones were distinguished by tandem mass spectrometry. Compounds 3 and 4 (derived from 3- and 4-hydroxy salicylaldehyde) as well as 8 and 9 (derived from 3- and 5-chloro salicylaldehyde) were distinguished by MS/MS as a result of "ortho effect". The MS/MS spectra and fragmentation pathways of compounds 6 and 7 (derived from 3- and 4-methoxy salicylaldehyde, respectively) differ due to enolimino-ketoamino tautomeric interconversion of 6. Homolytic cleavage and formation of radical cation was observed for compound 11, bearing nitro group in meta position with respect to C=N double bond. The fragmentation patterns of sodium adduct ions [M+Na]+ of the hydrazones were also investigated since the presence of an alkali metal influences the product-ion spectra.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Fidelta d.o.o.

Citiraj ovu publikaciju

Stražić, Dubravka; Benković, Tomislav; Gembarovski, Dubravka; Kontrec, Darko; Galić, Nives
Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide // International journal of mass spectrometry, 371 (2014), 54-64 doi:10.1016/j.ijms.2014.07.036 (međunarodna recenzija, članak, znanstveni)
Stražić, D., Benković, T., Gembarovski, D., Kontrec, D. & Galić, N. (2014) Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide. International journal of mass spectrometry, 371, 54-64 doi:10.1016/j.ijms.2014.07.036.
@article{article, year = {2014}, pages = {54-64}, DOI = {10.1016/j.ijms.2014.07.036}, keywords = {electrospray mass spectrometry, hydrazones, structural isomers, tautomerism, fragmentation}, journal = {International journal of mass spectrometry}, doi = {10.1016/j.ijms.2014.07.036}, volume = {371}, issn = {1387-3806}, title = {Comprehensive ESI MS and MS/MS analysis of aromatic hydrazones derived from nicotinic acid hydrazide}, keyword = {electrospray mass spectrometry, hydrazones, structural isomers, tautomerism, fragmentation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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