engleski

Mechanochemical C–H bond activation : rapid and regioselective double cyclopalladation monitored by in situ Raman Spectroscopy

The first direct mechanochemical transition- metal-mediated activation of strong phenyl C–H bonds is reported. Mechanochemical procedure, resulting in cyclopalladated complexes, is quantitative and significantly faster than solution synthesis and allows highly regioselective activation of two C–H bonds by palladium(II) acetate in asymmetrically substituted azobenzene. Milling is monitored by in situ solid-state Raman spectroscopy and in combination with quantum-chemical calculations enabled characterization of involved reaction species, direct insight into the dynamics and reaction pathways, as well as the optimization of a milling process.

C-H bond activation; palladium; azobenzene; Raman spectroscopy; mechanochemistry

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