Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience (CROSBI ID 207348)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dušek, Tina ; Kaštelan, Darko ; Melada, Ante ; Baretić, Maja ; Škorić Polovina, Tanja ; Perković, Zdravko ; Giljević, Zlatko ; Jelčić, Jozo ; Paladino, Josip ; Aganović, Izet ; Koršić, Mirko
engleski
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience
The aim of this study was to review the outcome of acromegaly treatment, as well as co-morbidity and mortality in a series of patients with acromegaly attending a single center in the last 10 yr. In that period, 53 patients were treated for acromegaly. Transsphenoidal operation was applied as the first-line therapy in 94.3% of patients and it led to disease remission in 59.2% of them. The remission criteria included a nadir GH<1 μg/l after glucose load, and normal age-related IGF-I levels. The remission rate after transsphenoidal surgery was significantly higher in the group of patients with microadenoma (76.9%), than in the group of patients with macroadenoma (52.8%). Patients with invasive tumors had remission rate of 16.7% after transsphenoidal surgery. There were no perioperative deaths. As the second-line treatment somatostatin analogues, radiotherapy, and dopaminergic agonists were used. Hypertension and diabetes were the most frequent co-morbidities in the group of patients. After successful treatment, 30% of patients with diabetes or impaired glucose tolerance had significant improvement of glycemic control. Transsphenoidal surgery is the appropriate firstline therapy in patients with somatotropinoma. Medical and radio-therapy should be reserved as the second-line therapy after surgery failure.
acromegaly ; acromegaly treatment ; pituitary adenoma ; transsphenoidal surgery
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Podaci o izdanju
34 (11)
2011.
382-385
objavljeno
0391-4097
1720-8386
10.3275/7858
Povezanost rada
Kliničke medicinske znanosti