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Pregled bibliografske jedinice broj: 705529

Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience


Dušek, Tina; Kaštelan, Darko; Melada, Ante; Baretić, Maja; Škorić Polovina, Tanja; Perković, Zdravko; Giljević, Zlatko; Jelčić, Jozo; Paladino, Josip; Aganović, Izet; Koršić, Mirko
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience // Journal of endocrinological investigation, 34 (2011), 11; 382-385 doi:10.3275/7858 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 705529 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience

Autori
Dušek, Tina ; Kaštelan, Darko ; Melada, Ante ; Baretić, Maja ; Škorić Polovina, Tanja ; Perković, Zdravko ; Giljević, Zlatko ; Jelčić, Jozo ; Paladino, Josip ; Aganović, Izet ; Koršić, Mirko

Izvornik
Journal of endocrinological investigation (0391-4097) 34 (2011), 11; 382-385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acromegaly ; acromegaly treatment ; pituitary adenoma ; transsphenoidal surgery

Sažetak
The aim of this study was to review the outcome of acromegaly treatment, as well as co-morbidity and mortality in a series of patients with acromegaly attending a single center in the last 10 yr. In that period, 53 patients were treated for acromegaly. Transsphenoidal operation was applied as the first-line therapy in 94.3% of patients and it led to disease remission in 59.2% of them. The remission criteria included a nadir GH<1 μg/l after glucose load, and normal age-related IGF-I levels. The remission rate after transsphenoidal surgery was significantly higher in the group of patients with microadenoma (76.9%), than in the group of patients with macroadenoma (52.8%). Patients with invasive tumors had remission rate of 16.7% after transsphenoidal surgery. There were no perioperative deaths. As the second-line treatment somatostatin analogues, radiotherapy, and dopaminergic agonists were used. Hypertension and diabetes were the most frequent co-morbidities in the group of patients. After successful treatment, 30% of patients with diabetes or impaired glucose tolerance had significant improvement of glycemic control. Transsphenoidal surgery is the appropriate firstline therapy in patients with somatotropinoma. Medical and radio-therapy should be reserved as the second-line therapy after surgery failure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
MZOS-108-1080231-0022 - ISTRAŽIVANJE UČINKOVITOSTI FUNKCIJSKIH NEUROKIRURŠKIH ZAHVATA (Paladino, Josip, MZOS ) ( POIROT)

Ustanove:
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Dušek, Tina; Kaštelan, Darko; Melada, Ante; Baretić, Maja; Škorić Polovina, Tanja; Perković, Zdravko; Giljević, Zlatko; Jelčić, Jozo; Paladino, Josip; Aganović, Izet; Koršić, Mirko
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience // Journal of endocrinological investigation, 34 (2011), 11; 382-385 doi:10.3275/7858 (međunarodna recenzija, članak, znanstveni)
Dušek, T., Kaštelan, D., Melada, A., Baretić, M., Škorić Polovina, T., Perković, Z., Giljević, Z., Jelčić, J., Paladino, J., Aganović, I. & Koršić, M. (2011) Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience. Journal of endocrinological investigation, 34 (11), 382-385 doi:10.3275/7858.
@article{article, year = {2011}, pages = {382-385}, DOI = {10.3275/7858}, keywords = {acromegaly, acromegaly treatment, pituitary adenoma, transsphenoidal surgery}, journal = {Journal of endocrinological investigation}, doi = {10.3275/7858}, volume = {34}, number = {11}, issn = {0391-4097}, title = {Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience}, keyword = {acromegaly, acromegaly treatment, pituitary adenoma, transsphenoidal surgery} }
@article{article, year = {2011}, pages = {382-385}, DOI = {10.3275/7858}, keywords = {acromegaly, acromegaly treatment, pituitary adenoma, transsphenoidal surgery}, journal = {Journal of endocrinological investigation}, doi = {10.3275/7858}, volume = {34}, number = {11}, issn = {0391-4097}, title = {Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience}, keyword = {acromegaly, acromegaly treatment, pituitary adenoma, transsphenoidal surgery} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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