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Pregled bibliografske jedinice broj: 704643

Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny


Žubčić, Damir; Kovšca Janjatović, Ana; Kezić, Dubravko; Špoljarić, Daniel; Valpotić, Hrvoje; Lacković, Gordana; Anđelinović, Deny; Mršić, Gordan; Popović, Maja
Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny // Veterinarski arhiv. Supplement, 84 (2014), 3; 265-278 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 704643 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny

Autori
Žubčić, Damir ; Kovšca Janjatović, Ana ; Kezić, Dubravko ; Špoljarić, Daniel ; Valpotić, Hrvoje ; Lacković, Gordana ; Anđelinović, Deny ; Mršić, Gordan ; Popović, Maja

Izvornik
Veterinarski arhiv. Supplement (0372-5480) 84 (2014), 3; 265-278

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
postnatal development; immune cells; gut mucosa; pigs.

Sažetak
By using immunohistology and digital image analysis for histomorphometry we have investigated the influence of porcine postnatal development on distribution and quantitative patterns of naïve/memory lymphoid cell subsets (CD45RA+, CD45RC+, respectively), helper/cytotoxic T cell subsets (CD4+, CD8+, respectively) as well as of IgA+ plasma cells in the gut-associated lymphoid tissues (GALT) of the pigs reared under intensive conditions during the first 7 weeks of life. Current research on postnatal ontogenesis/maturation of porcine small intestinal mucosal immune system have shown that the newborn pigs were immunologically rather immature and, thus, totally dependent on passively acquired immunity. Their jejunal mucosa almost lack the immune cells, with exception of a low number of CD45RA+ lymphoid cells (1.25 x 10-5) at Day 0 post partum. A very few CD45RC+ lymphoid cells (8.79 x 10-6 ) appeared at Day 7 followed by a similar number of IgA+ plasma cells (7.65 x 10-6) which were observed at Day 14. Such first signs of postnatal development of both innate and adaptive immunity by identification/localization of tested cell subsets residing porcine GALT, i e. jejunal mucosal sites are proceeded with a lag period of three weeks until appearance of low numbers of CD4+ (3.62 x 10-5) and CD8+ (3.13 x 10-5) T cells at Day 35 after birth. After that phase of an early postnatal development of the crucial cell subsets participating in the antigen-specific immunity at the gut mucosal surfaces of young pigs, further progress is visible through their different distribution patterns within jejunal mucosa compartments and gradual increase in their numbers particularly between Day 35 and Day 49 of age. A significant increase was recorded within that period for the numbers of naïve, memory and plasma cells whereas the numbers of helper and cytotoxic T cells were only slightly increased between Day 42 and Day 49 of life

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

Napomena
Rad je vezan uz istraživanja VIP projekta:2012-11-17 naziva: MODULACIJA IMUNOSTI ZDRAVLJA KAO ALTERNATIVA ANTIBIOTICIMA U UZGOJU KONZUMNIH ŽIVOTINJA voditeljice prof. dr. sc. Maje Popović



POVEZANOST RADA


Projekti:
VIP projekt 2012-11-17
053-0532265-2255 - Kolidiareja i kolienterotoksemija prasadi : mukozna imunost i imunomodulacija (Popović, Maja, MZOS ) ( POIROT)

Ustanove:
Veterinarski fakultet, Zagreb


Citiraj ovu publikaciju:

Žubčić, Damir; Kovšca Janjatović, Ana; Kezić, Dubravko; Špoljarić, Daniel; Valpotić, Hrvoje; Lacković, Gordana; Anđelinović, Deny; Mršić, Gordan; Popović, Maja
Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny // Veterinarski arhiv. Supplement, 84 (2014), 3; 265-278 (međunarodna recenzija, članak, znanstveni)
Žubčić, D., Kovšca Janjatović, A., Kezić, D., Špoljarić, D., Valpotić, H., Lacković, G., Anđelinović, D., Mršić, G. & Popović, M. (2014) Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny. Veterinarski arhiv. Supplement, 84 (3), 265-278.
@article{article, author = {\v{Z}ub\v{c}i\'{c}, Damir and Kov\v{s}ca Janjatovi\'{c}, Ana and Kezi\'{c}, Dubravko and \v{S}poljari\'{c}, Daniel and Valpoti\'{c}, Hrvoje and Lackovi\'{c}, Gordana and An\djelinovi\'{c}, Deny and Mr\v{s}i\'{c}, Gordan and Popovi\'{c}, Maja}, year = {2014}, pages = {265-278}, keywords = {postnatal development, immune cells, gut mucosa, pigs.}, journal = {Veterinarski arhiv. Supplement}, volume = {84}, number = {3}, issn = {0372-5480}, title = {Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny}, keyword = {postnatal development, immune cells, gut mucosa, pigs.} }
@article{article, author = {\v{Z}ub\v{c}i\'{c}, Damir and Kov\v{s}ca Janjatovi\'{c}, Ana and Kezi\'{c}, Dubravko and \v{S}poljari\'{c}, Daniel and Valpoti\'{c}, Hrvoje and Lackovi\'{c}, Gordana and An\djelinovi\'{c}, Deny and Mr\v{s}i\'{c}, Gordan and Popovi\'{c}, Maja}, year = {2014}, pages = {265-278}, keywords = {postnatal development, immune cells, gut mucosa, pigs.}, journal = {Veterinarski arhiv. Supplement}, volume = {84}, number = {3}, issn = {0372-5480}, title = {Identification, localization and quantification of porcine intestinal immune cell subsets during the first seven weeks of postnatal ontogeny}, keyword = {postnatal development, immune cells, gut mucosa, pigs.} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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