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Pregled bibliografske jedinice broj: 704127

Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox?


Laganović, Mario; Bendix, Laila; Rubelj, Ivica; Vrkić Kirhmajer, Majda; Slade, Neda; Vuković Lela, Ivana; Premužić, Vedran; Nilssonf, Peter M.; Jelaković, Bojan
Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox? // Journal of hypertension, 32 (2014), 8; 1613-1620 doi:10.1097/HJH.0000000000000217 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 704127 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox?

Autori
Laganović, Mario ; Bendix, Laila ; Rubelj, Ivica ; Vrkić Kirhmajer, Majda ; Slade, Neda ; Vuković Lela, Ivana ; Premužić, Vedran ; Nilssonf, Peter M. ; Jelaković, Bojan

Izvornik
Journal of hypertension (0263-6352) 32 (2014), 8; 1613-1620

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cardiovascular diseases; fetal growth retardation; genetics; telomeres

Sažetak
The mechanisms that increase cardiovascular risk in individuals born small for gestational age (SGA) are not well understood. Telomere shortening has been suggested to be a predictor of disease onset. Our aim was to determine whether impaired intrauterine growth is associated with early signs of vascular aging and whether telomere length could be a biomarker of this pathway. METHODS: One hundred and fourteen healthy young men born SGA or after normal pregnancy [appropriate for gestational age (AGA)] were enrolled. Patient data were gathered from questionnaires and clinical exams, including blood pressure (BP) measurement routine laboratory analyses, and carotid intima- media thickness (cIMT). Leukocyte telomere length (LTL) was assessed by quantitative PCR. Birth data were obtained from medical records. RESULTS: The SGA group had significantly higher pulse pressure and cIMT, and a trend to increased SBP and heart rate in comparison to the AGA group. Interestingly, SGA men exhibited a 42% longer LTL than the AGA group. LTL was inversely associated with age, BMI, BP and birth parameters. In multiple regression analysis, BMI was the key determinant of SBP and cIMT. CONCLUSION: Young men born SGA show early signs of vascular aging. Unexpectedly, in our cohort, the SGA group had longer telomeres than the normal controls. Although longer telomeres are predictive of better health in the future, our findings could indicate a faster telomere attrition rate and probable early onset of cardiovascular risk in SGA participants. Follow-up of this cohort will clarify hypothesis and validate telomere dynamics as indicators of future health risks.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
098-0982464-2391 - Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka (Slade, Neda, MZOS ) ( POIROT)
098-0982913-2768 - Struktura i funkcija telomera u kontroli staničnog rasta (Rubelj, Ivica, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Laganović, Mario; Bendix, Laila; Rubelj, Ivica; Vrkić Kirhmajer, Majda; Slade, Neda; Vuković Lela, Ivana; Premužić, Vedran; Nilssonf, Peter M.; Jelaković, Bojan
Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox? // Journal of hypertension, 32 (2014), 8; 1613-1620 doi:10.1097/HJH.0000000000000217 (međunarodna recenzija, članak, znanstveni)
Laganović, M., Bendix, L., Rubelj, I., Vrkić Kirhmajer, M., Slade, N., Vuković Lela, I., Premužić, V., Nilssonf, P. & Jelaković, B. (2014) Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox?. Journal of hypertension, 32 (8), 1613-1620 doi:10.1097/HJH.0000000000000217.
@article{article, year = {2014}, pages = {1613-1620}, DOI = {10.1097/HJH.0000000000000217}, keywords = {cardiovascular diseases, fetal growth retardation, genetics, telomeres}, journal = {Journal of hypertension}, doi = {10.1097/HJH.0000000000000217}, volume = {32}, number = {8}, issn = {0263-6352}, title = {Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox?}, keyword = {cardiovascular diseases, fetal growth retardation, genetics, telomeres} }
@article{article, year = {2014}, pages = {1613-1620}, DOI = {10.1097/HJH.0000000000000217}, keywords = {cardiovascular diseases, fetal growth retardation, genetics, telomeres}, journal = {Journal of hypertension}, doi = {10.1097/HJH.0000000000000217}, volume = {32}, number = {8}, issn = {0263-6352}, title = {Reduced telomere length is not associatedwith early signs of vascular aging in youngmen born after intrauterine growth restriction : a paradox?}, keyword = {cardiovascular diseases, fetal growth retardation, genetics, telomeres} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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