engleski

Bone Mineral Density Across Diverse Geographical and Racial Populations

We examined differences in bone mineral density of young adults (15-50 years) across a range of races and countries. An age-stratified total of 3752 subjects were recruited at 11 centres in 9 countries. Femoral neck BMD was measured and standardised (sBMD, g/cm2) using the European Spine Phantom. There were highly significant differences in mean weight, height, and sBMD between countries (p<0.001). Moscow had the highest mean sBMD and was used as the reference population in linear regression models. Following adjustment for age, weight and height, differences in sBMD persisted between centres for both men and women. Centre sBMD difference Significance Santiago -0.001ą0.013 0.930 Ankara -0.012ą0.012 0.318 Obninsk -0.025ą0.017 0.131 Beijing -0.025ą0.011 0.026 Toronto -0.029ą0.014 0.035 Singapore -0.047ą0.012 <0.001 Sau Paulo -0.058ą0.014 <0.001 Manila -0.062ą0.014 <0.001 Debrecan -0.071ą0.012 <0.001 Shanghai -0.088ą0.013 <0.001 Table. Differences in female sBMD (meanąSEM) compared to Moscow. Approximately 20-30% of the global variation in sBMD is accounted for by country of origin and anthropomorphic differences. Significant differences exist in young adult bone mass which, if persisting into old age, may contribute to 2-3 fold difference in fracture risk.

nije evidentirano

nije evidentirano