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Pregled bibliografske jedinice broj: 703384

Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants


Cuthbertson, Daniel J.; Johnson, Sean R.; Piljac- Žegarac, Jasenka; Kappel, Julia, Schafer, Sarah; Wust, Matthias; Ketchum, Raymond E. B.; Croteau, Rodney B.; Marques, Joaquim V.; Davin, Laurence B.; Lewis, Norman G. et al.
Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants // Phytochemistry, 91 (2013), 187-197 doi:10.1016/j.phytochem.2013.02.018 (međunarodna recenzija, članak, znanstveni)


Naslov
Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants

Autori
Cuthbertson, Daniel J. ; Johnson, Sean R. ; Piljac- Žegarac, Jasenka ; Kappel, Julia, Schafer, Sarah ; Wust, Matthias ; Ketchum, Raymond E. B. ; Croteau, Rodney B. ; Marques, Joaquim V. ; Davin, Laurence B. ; Lewis, Norman G. ; Rolf, Megan ; Kutchan, Toni M. ; Soejarto, Doel D. ; Lange, Markus B.

Izvornik
Phytochemistry (0031-9422) 91 (2013); 187-197

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
AMT tag library ; mass spectrometry ; metabolomics ; natural product

Sažetak
We report the development and testing of an accurate mass - time (AMT) tag approach for the LC/MS-based identification of plant natural products (PNPs) in complex extracts. An AMT tag library was developed for approximately 500 PNPs with diverse chemical structures, detected in electrospray and atmospheric pressure chemical ionization modes (both positive and negative polarities). In addition, to enable peak annotations with high confidence, MS/MS spectra were acquired with three different fragmentation energies. The LC/MS and MS/MS data sets were integrated into online spectral search tools and repositories (Spektraris and MassBank), thus allowing users to interrogate their own data sets for the potential presence of PNPs. The utility of the AMT tag library approach is demonstrated by the detection and annotation of active principles in 27 different medicinal plant species with diverse chemical constituents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Jasenka Piljac Žegarac (autor)

Citiraj ovu publikaciju

Cuthbertson, Daniel J.; Johnson, Sean R.; Piljac- Žegarac, Jasenka; Kappel, Julia, Schafer, Sarah; Wust, Matthias; Ketchum, Raymond E. B.; Croteau, Rodney B.; Marques, Joaquim V.; Davin, Laurence B.; Lewis, Norman G. et al.
Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants // Phytochemistry, 91 (2013), 187-197 doi:10.1016/j.phytochem.2013.02.018 (međunarodna recenzija, članak, znanstveni)
Cuthbertson, D., Johnson, S., Piljac- Žegarac, J., Kappel, Julia, Schafer, Sarah, Wust, M., Ketchum, R., Croteau, R., Marques, J., Davin, L. & Lewis, N. (2013) Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants. Phytochemistry, 91, 187-197 doi:10.1016/j.phytochem.2013.02.018.
@article{article, year = {2013}, pages = {187-197}, DOI = {10.1016/j.phytochem.2013.02.018}, keywords = {AMT tag library, mass spectrometry, metabolomics, natural product}, journal = {Phytochemistry}, doi = {10.1016/j.phytochem.2013.02.018}, volume = {91}, issn = {0031-9422}, title = {Accurate mass - time tag library for LC/MS-based metabolite profiling of medicinal plants}, keyword = {AMT tag library, mass spectrometry, metabolomics, natural product} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • CAB Abstracts


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