engleski

Impact of mothers nutrition and nutrition of offspring on glucose levels in male offspring

Introduction: Rates of overweight and obesity in women of childbearing age continue to increase world-wide. In response to maternal overnutrition in pregnancy it is now well established that the children are more likely to increase susceptibility to obesity, cardiovascular disease, and glucose intolerance in later life. The aim of the study is to determine the effect of maternal diet on glucose levels in male offspring. Methods: Ten female Sprague Dawley rats were at the age of 21 days divided in two groups, one was fed with high-fat diet (HFD ; n = 5), the other one had free access to standard laboratory chow (CD ; n = 5). At the age of 12 weeks, the rats were mated, and their offspring were randomly dived in 3 groups after the lactation period (CD-HFD n = 35, HFD-CD n = 35, HFD-HFD n = 35). In all three groups at the age of 36 days, the offspring were sacrificed and blood samples were collected. Results: HFD-CD and CD-HFD rats had the lowest weight after birth, but their weight increased the most compared to control and HFD-HFD rats. HFD-CD group had lowest median in compared to weights of other groups. Blood glucose levels were lowest in the HFD-CD group (5.5 ± 0.90), while CD-HFD (10.3 ± 1.72) and HFD-HFD (9.0 ± 1.32) groups had similar levels of blood glucose.

high-fat diet; glucose; offspring; epigenetic

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