engleski

Non-Linearity between anthropometric measures, subcutaneous adipose tissue thickness and thickness of epicardial adipose tissues

Introduction: Adipose tissue is the largest endocrine organ, mostly located under the skin, as subcutaneous adipose tissue (SAT), and around visceral organs, as visceral adipose tissue (VAT), the latter being highly correlated with coronary artery disease (CAD) and other metabolic conditions. One way of assessing the CAD risk and metabolic risk is by use of low-cost anthropometric measures, although it is known that they are inaccurate, and cannot discriminate between VAT and SAT. Thickened epicardial adipose tissues (EAT ; part of VAT) was recently linked with severity of CAD. Therefore, we aimed to assess, in detail, the nature of relationships among anthropometric measures, SAT and EAT thickness. Methods: Anthropometric measures were obtained from 53 CAD and 42 age and BMI matched nonCAD patients. Vascular and structural statuses were obtained with coronarography and echocardiography, as well as measurements of the EAT and SAT thickness. Results: Anthropometric measures and SAT thickness follow a non-linear S curve relationship with EAT thickness. EAT thickness and SAT thinner than 10 mm have a strong, non-linear power curve relationship. Thickening of SAT above 10 mm is independent of EAT thickness. Conclusion: Anthropometric measures and SAT have a non-linear relationship with EAT possibly due to adipose tissue remodeling that develops with hypoxia, which is more prominent in VAT.

SAT thickness; EAT thickness; CAD risks

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