THE RELATIONSHIP BETWEEN ANTI-MüLLERIAN HORMONE (AMH) CONCENTRATION AND OLIGO/AMENORRHOEA IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN MORPHOLOGY (CROSBI ID 612369)
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Podaci o odgovornosti
Alebić, Miro Šimun ; Stojanović, Nataša
engleski
THE RELATIONSHIP BETWEEN ANTI-MüLLERIAN HORMONE (AMH) CONCENTRATION AND OLIGO/AMENORRHOEA IN SUBFERTILE WOMEN WITH POLYCYSTIC OVARIAN MORPHOLOGY
BACKGROUND: Serum anti-Müllerian hormone (AMH) concentration is related to hyperandrogenism (HA) and oligo/amenorrhoea (OA) of polycystic ovary syndrome (PCOS). Objectives of this study were firstly to determine whether AMH is predominantly associated with OA or HA in subfertile women diagnosed as having PCOS according to the Rotterdam criteria (RC) and secondly to determine whether AMH association with the number of follicles measuring 2-9 mm in diameter (AFC) is independent of other clinical and biochemical characteristics that define PCOS. METHODS: A total of 233 subfertile women with polycystic ovarian morphology (PCOM) who met the RC criteria for PCOS were divided into phenotype groups as follows: PCOS A = PCOM+HA+OA, n=90 ; PCOS C = PCOM+HA, n=51 ; PCOS D = PCOM+OA, n=91. PCOM was defined as the presence of >11 AFC in at least one ovary. HA was defined as testosterone (T) concentration >2.8 nmol/L and/or modified Ferriman-Gallwey score (mFG) >7. OA was defined as menstrual cycle length (MCL) >35 days. Kruskal-Walis test with post-hoc analysis for pair wise comparison was used to determine the between-group difference in AMH and other patient characteristics. The relationships between AMH and patient characteristics that define RC were assessed by multiple regression analysis (MRA). P-value <0.05 was considered as statistically significant. RESULTS: Significant difference in AMH was found when two hyperandrogenic PCOS phenotypes differing in MCL (PCOS A vs PCOS C) were compared to each other (P < 0.001). In contrast, the AMH values of the two oligo/anovulatory PCOS phenotypes (PCOS A vs PCOS D) did not differ despite the difference in the signs of HA (P = 0.174). AMH was found to be associated with AFC, T and MCL, but not with mFG. MRA revealed an independent association between AMH and AFC. AMH was included together with MCL, T and mFG in the AFC prediction model explaining 36.9% of the variance of AFC. CONCLUSIONS: OA seems to be the PCOS feature predominantly associated with the AMH concentration in PCOS women having PCOM. The antral follicle accumulation in PCOS could be partially explained by an androgen-independent role of AMH.
AMH; polycystic ovary syndrome; oligo/amenorrhoea
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Podaci o prilogu
S0608-S0608.
2014.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Clinical chemistry and laboratory medicine
Plebani, Mario
Berlin: Walter de Gruyter
1434-6621
Podaci o skupu
IFCC WorldLab Istanbul 2014
poster
22.06.2014-26.06.2014
Istanbul, Turska