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rhBMP-7 treated IRBR implants on rat calvarial defects (CROSBI ID 612300)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Zoričić Cvek, Sanja ; Đudarić, Luka ; Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina rhBMP-7 treated IRBR implants on rat calvarial defects // 6th International Symposium of Clinical and Applied Anatomy - Book of Abstracts / Zoričić Cvek, Sanja (ur.). Rijeka, 2014. str. 50-50

Podaci o odgovornosti

Zoričić Cvek, Sanja ; Đudarić, Luka ; Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina

engleski

rhBMP-7 treated IRBR implants on rat calvarial defects

Aim: The cellular and molecular sequences of the osteogenesis induced by rhBMP-7 bound to inactive rat bone residue (IRBR) as a carrier implanted in rats have been studied at calvarial defect. Methods and experimental design: To create a parcial defect of calvarial rat bone, periosteum and bone of the frontoparietooccipital complex were grinded with dental burr and special care was taken to avoid cranial wall opening. The implants were harvested at day 7th, 12th and 21th. Tissue samples were analysed by histology, histochemistry and histomorphometry. Results: The results of this study showed different initial tissue response in relation to control samples of implants (contain no active osteoinductive BMP-7). On rat calvarial deffect BMP-7 induced direct bone formation (intramembranous bone formation) and fuses with the underlying bone deffect. In the underlying bone remodeling is active as early as day 12th and is completely fused with the impalnt by day 21st.The results of histomorphometry showed more prounanced and rapid osteogenesis in relation to control animals. Conclusion: The results of this study suggest that rhBMP-7 induced early bone formation and promote osteogenesis to deffect healing. The bone forming process is manly direct ie. intramembranous bone formation.

rhBMP-7; IRBR implants; bone

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Podaci o prilogu

50-50.

2014.

objavljeno

Podaci o matičnoj publikaciji

6th International Symposium of Clinical and Applied Anatomy - Book of Abstracts

Zoričić Cvek, Sanja

Rijeka:

Podaci o skupu

6th International Symposium of Clinical and Applied Anatomy

poster

26.06.2014-29.06.2014

Rijeka, Hrvatska; Malinska, Hrvatska

Povezanost rada

Temeljne medicinske znanosti