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Involvement of bradykinin in brain edema development after ischemic stroke

Dobrivojević, Marina; Špiranec, Katarina; Sinđić, Aleksandra
Involvement of bradykinin in brain edema development after ischemic stroke // Pflügers Archiv, 467 (2014), 2; 201-212 doi:10.1007/s00424-014-1519-x (međunarodna recenzija, pregledni rad, znanstveni)

Involvement of bradykinin in brain edema development after ischemic stroke

Dobrivojević, Marina ; Špiranec, Katarina ; Sinđić, Aleksandra

Pflügers Archiv (0031-6768) 467 (2014), 2; 201-212

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Brain ischemic injury; brain edema formation; Bradykinin signaling pathways; new therapeutic targets

Stroke is the third leading cause of death in the Western world. Ischemic stroke is characterized by a rapid loss of brain function due to disturbance in the blood supply to a part of the brain. Due to fixed intracranial space, any increase in intracranial fluid volume, or progressive brain edema formation, contributes to further deterioration of the already impaired brain function. Bradykinin increases blood–brain barrier permeability and raises intracranial capillary blood pressure by arterial dilatation and venous constriction leading to brain edema formation. The aim of this paper is to summarize the recent research in the field of bradykinin function (structure, synthesis, signaling pathways, mechanism of action) followed by characterization of different types of brain edema development related to ischemic brain injury, together with the involvement of bradykinin in edema formation. Since there is currently no causal treatment addressing brain edema after ischemic stroke, specific bradykinin receptor antagonists are proposed as a possible new therapeutic approach.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti


Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Zdravstveno veleučilište, Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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