Patterns of genomic inbreeding in worldwide sheep populations (CROSBI ID 612266)
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Podaci o odgovornosti
Curik, Ino ; Ferenčaković, Maja ; Šalamon, Dragica ; Sölkner, Johann ; Lenstra, A. Johannes ; International Sheep Genomic Consortium
engleski
Patterns of genomic inbreeding in worldwide sheep populations
Inbreeding is a fundamental parameter in conservation genetics of any small population as its increase results in the reduction of effective population size, increase in frequency of deleterious alleles and the concomitant inbreeding depression of fitness and fertility. We have inferred levels of inbreeding in 77 sheep populations (2938 individuals) from different continents, using individual runs of homozygosity (ROH) estimates of 4, 8 and 16 Mb in 47502 autosomal SNPs and expressed as the coefficients FROH>4Mb, FROH>8Mb and FROH>16Mb. Inbreeding level estimates ranged from 0.005 (Rasa Aragonesa) to 0.309 (MacArthur Merino) for FROH>4Mb (average 0.07) as maximal values, from 0.002 (Rasa Aragonesa) to 0.202 (MacArthur Merino) for FROH>8Mb (average 0.047) and from 0.001 (Rasa Aragonesa) to 0.090 (Wiltshire) for FROH>16Mb, ( average 0.025). Pearson correlations among inbreeding levels ranged from 0.877 (FROH>4Mb : FROH>16Mb) to 0.974 (FROH>4Mb : FROH>8Mb). Negative Pearson correlations between allele richness/ (observed heterozygosity) were decreasing with ROH lengths from -0.746/ (-0.823) for FROH>4Mb, but lower for longer ROHs to (-0.533/ (-0.688) for FROH>16Mb). In addition, uUsing linear statistical modeling, we have analyzed the impact of crossbreeding, geographic location of a breed, use of artificial insemination and main type of production as well as the effect of chromosome location, chromosome length and recombination rates on the ROH-derived inbreeding levels.
Inbreeding; ROH pattern; Worldwide sheep populations
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Podaci o prilogu
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Podaci o skupu
Livestock Genomic Resources in a Changing World Conference
poster
17.06.2014-19.06.2014
Cardiff, Ujedinjeno Kraljevstvo