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Modeling genome wise dissection of inbreeding depression for bull fertility traits (CROSBI ID 612264)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Ferenčaković, Maja ; Curik, Ino ; Sölkner, Johann Modeling genome wise dissection of inbreeding depression for bull fertility traits // Program and Abstracts of Livestock Genomic Resources in a Changing World Conference / Bruford, Michael W. ; Orozco-terWengel, Pablo ; Costa, Mafalda (ur.). Cardiff, 2014. str. 17-17

Podaci o odgovornosti

Ferenčaković, Maja ; Curik, Ino ; Sölkner, Johann

engleski

Modeling genome wise dissection of inbreeding depression for bull fertility traits

In spite of inbreeding depression importance, its genetic basis is still unclear. To dissect genetic architecture of inbreeding depression, we provided a genetic model that enables estimation of inbreeding depression at the single SNP level using information of allele frequencies (p and q), dominance effect estimates (d) and mean SNP autozygosity in the population (fSNP). Our models were tested on the fertility traits measured on 162 Brown Swiss bulls from Artificial Insemination station Birkenberg (Tyrol, Austria), genotyped with the Bovine SNP50 Beadchip (v1.). After editing, data consisted of 8756 recorded ejaculates with information for volume of ejaculate (VE ml), concentration of ejaculate (CE 109/ml) and percent of viable spermatozoa (VS %) and 28792 SNPs. Runs of Homozygosity (ROH) were used to estimate individual inbreeding coefficients (FROH>4 Mb) as well as to determine mean autozygosity of each SNP in the population (fSNP). Results obtained indicated polygenic pattern of inbreeding depression as the highest contributions of single SNP were 0.06% (VE), 0.04% (CE) and 0.05% (VS) of the overall genome-wise 2pqdfSNP score (|∑2pqdfSNP|). The percentage of all SNPs with showing over- or under- dominance (absolute dominance over additive effects ratio |d/a|>1) was 56.1%, 55.7% and 59% for VE, CE and VS, respectively. However, this percentage was reduced to 22.5% (416/1852) for VE, 16.0% (216/1349) for CE and 27.7% (660/2382) for VS when only SNPs with significant (P<0.05) additive effects were considered. All three traits exhibited inbreeding depression defined by negative ∑2pqdfSNP value, calculated over all SNPs.

Inbreeding depression; Mapping; Fertility traits

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Podaci o prilogu

17-17.

2014.

objavljeno

Podaci o matičnoj publikaciji

Program and Abstracts of Livestock Genomic Resources in a Changing World Conference

Bruford, Michael W. ; Orozco-terWengel, Pablo ; Costa, Mafalda

Cardiff:

Podaci o skupu

Livestock Genomic Resources in a Changing World Conference

predavanje

17.06.2014-19.06.2014

Cardiff, Ujedinjeno Kraljevstvo

Povezanost rada

Biotehnologija