Modeling genome wise dissection of inbreeding depression for bull fertility traits (CROSBI ID 612264)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ferenčaković, Maja ; Curik, Ino ; Sölkner, Johann
engleski
Modeling genome wise dissection of inbreeding depression for bull fertility traits
In spite of inbreeding depression importance, its genetic basis is still unclear. To dissect genetic architecture of inbreeding depression, we provided a genetic model that enables estimation of inbreeding depression at the single SNP level using information of allele frequencies (p and q), dominance effect estimates (d) and mean SNP autozygosity in the population (fSNP). Our models were tested on the fertility traits measured on 162 Brown Swiss bulls from Artificial Insemination station Birkenberg (Tyrol, Austria), genotyped with the Bovine SNP50 Beadchip (v1.). After editing, data consisted of 8756 recorded ejaculates with information for volume of ejaculate (VE ml), concentration of ejaculate (CE 109/ml) and percent of viable spermatozoa (VS %) and 28792 SNPs. Runs of Homozygosity (ROH) were used to estimate individual inbreeding coefficients (FROH>4 Mb) as well as to determine mean autozygosity of each SNP in the population (fSNP). Results obtained indicated polygenic pattern of inbreeding depression as the highest contributions of single SNP were 0.06% (VE), 0.04% (CE) and 0.05% (VS) of the overall genome-wise 2pqdfSNP score (|∑2pqdfSNP|). The percentage of all SNPs with showing over- or under- dominance (absolute dominance over additive effects ratio |d/a|>1) was 56.1%, 55.7% and 59% for VE, CE and VS, respectively. However, this percentage was reduced to 22.5% (416/1852) for VE, 16.0% (216/1349) for CE and 27.7% (660/2382) for VS when only SNPs with significant (P<0.05) additive effects were considered. All three traits exhibited inbreeding depression defined by negative ∑2pqdfSNP value, calculated over all SNPs.
Inbreeding depression; Mapping; Fertility traits
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Podaci o prilogu
17-17.
2014.
objavljeno
Podaci o matičnoj publikaciji
Program and Abstracts of Livestock Genomic Resources in a Changing World Conference
Bruford, Michael W. ; Orozco-terWengel, Pablo ; Costa, Mafalda
Cardiff:
Podaci o skupu
Livestock Genomic Resources in a Changing World Conference
predavanje
17.06.2014-19.06.2014
Cardiff, Ujedinjeno Kraljevstvo