engleski

The regulation of programmed necrosis and intrinsic apoptotic pathway following DNA damage is FADD dependent

Cell death can be morphologically described as apoptosis or necrosis. Apoptosis can be induced via activation of intrinsic or extrinsic apoptotic pathway. Necrosis can be regulated via RIP1-kinase signaling and then it is called necroptosis. Adaptor protein FADD (Fas- associated death domain) in lymphocytes acts as a positive regulator of apoptosis and negative regulator of necroptosis in signal transduction from cell death receptors to caspase 8 or RIP1 kinase. There were differences reported regarding the role of FADD in the regulation of necroptosis which were dependent of cell type and cell death inducer. As a cell death inducer we used UVB irradiation, a potential carcinogen.

UVB irradiation; adaptor protein FADD; necroptosis; Bcl-2; Bax

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