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Pregled bibliografske jedinice broj: 701823

Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer


Štajduhar, Emil; Sedić, Mirela; Leniček, Tanja; Radulović, Petra; Kerenji, Aleksandar; Krušlin, Božo; Pavelić, Krešmir; Kraljević Pavelić, Sandra
Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer // Tumor biology, 35 (2014), 7; 6425-6434 (međunarodna recenzija, članak, znanstveni)


Naslov
Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer

Autori
Štajduhar, Emil ; Sedić, Mirela ; Leniček, Tanja ; Radulović, Petra ; Kerenji, Aleksandar ; Krušlin, Božo ; Pavelić, Krešmir ; Kraljević Pavelić, Sandra

Izvornik
Tumor biology (1010-4283) 35 (2014), 7; 6425-6434

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Breast cancer; metastasis; growth hormone; growth hormone receptor; plakoglobin; NEDD9

Sažetak
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths among female population worldwide. Metastases are the common cause of morbidity and mortality in breast cancer, and can remain latent for several years after surgical removal of the primary tumour. Thus, the identification and functional characterisation of molecular factors that promote oncogenic signalling in mammary tumour development and progression could provide new entry points for designing targeted therapeutic strategies for metastatic breast cancer. In the present study, we investigated the expression of proteins involved in cell signalling (GHR and NEDD9) and cell-cell adhesion (plakoglobin) in epithelial and stromal compartments of primary ductal invasive breast carcinomas and their axillary lymph node metastases versus non-metastatic tumours. Obtained data revealed remarkable increase in the expression levels of GHR and NEDD9 proteins in both, epithelial and stromal components of axillary lymph node metastases in comparison with non-metastatic tumours suggesting that the expression of these two proteins may provide biomarkers for tumour aggressiveness

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Božo Krušlin, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE