engleski

Leptin/Adiponectin ratio and relation with lipidogram in overweight, hypertensive patients with cardiovascular event

Objective: According to recent studies, leptin/adiponectin ratio presents better marker of atherosclerosis, insulin resistance, metabolic syndrome and cardiovascular event than leptin and adiponectin concentrations alone. Most of the studies were done in obese individuals. This study analyses relationship between leptin/adiponectin ratio in early stages of increasing body fat, in overweight with developed metabolic syndrome and myocardial infarction in personal history. The aim of the study was to determine the relationship of cardiovascular risk factors with leptin/adiponectin ratio, to determine role of serum lipid levels in relation with leptin/adiponectin ratio but in overweight individuals. Design and method: Study included 80 patients (40 male, 40 female), body mass index 25-30 kg/m2, visceral type of obesity, dyslipidemia, hypertension and myocardial infarction in the personal history. Exclusive criteria were obesity, diabetes mellitus and renal disease. Anthropometric, biochemical and cardiovasular measurements were done to all individuals. Serum leptin concentration was measured with radioimmunoassay test and total adiponectin level with enzyme immunoassay test. Results: Leptin/adiponectin ratio is significantly lower in male group than in female group of subjects. Levels of cholesterol, triglycerides, LDL were higher and HDL was lower in male group according to reference values. Cholesterol and LDL were higher but triglycerides and HDL were in regular range in female group. The ratio of leptin/adiponectin showed no significant correlation in the male and female group of examiners with the level of cholesterol, triglycerides, LDL and HDL. Conclusion: In overweight persons (with central type of obesity, increased leptin level, decreased adiponectin level, hypertension, coronary disease but eithout diabetes mellitus) leptin/adiponectin ratio in relation with lipidogram concentrations showed that dyslipidemia is not main part of complex atherosclerotic patophysiology. Dyslipidemia is present in overweight with metabolic syndrome, but the other risk factors in these patients could be more important, such as hypertension. Also, it is important to emphasize gender differences in adipokine levels and ratio, which may be important in the pathophysiology of metabolic processec that affect individual to each risk factor.

leptin; adiponectin; obesity; cardiovascular risk

nije evidentirano