engleski

Resting heart rate and blood pressure are associated with gamma-glutamyltransferase in normoalbuminuric type 1 diabetic patients

GGT is an independent risk factor for development of hypertension, coronary artery disease, left ventricular diastolic dysfunction and chronic kidney disease. Blood pressure and heart rate (HR) is a strong and independent predictor of all-cause death and major cardiovascular complications and increased prevalence and severity of chronic kidney disease. The aim of this study was to explore the relationship between GGT, systolic and diastolic blood pressure and HR in type 1 diabetic patients with normal renal function. Study included 313 normoalbuminuric type 1 diabetic patients (estimated glomerular filtration rate (eGFR over 60 ml/min) with no medical history of liver, renal and cardiovascular diseases and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. In this study of normoalbuminuric type 1 diabetic patients we have shown that GGT is positively associated with systolic and diastolic blood pressure and HR. Higher GGT in type 1 diabetic patients may indicate that those subjects are not only at risk of hepatic disease, but also at risk of coronary artery disease and progression of renal disease.

hypertension; type 1 diabetes; γ-glutamyltransferase;

nije evidentirano