engleski

IDENTIFICATION, CHARACTERIZATION AND ECOTOXICOLOGICAL RELEVANCE OF MEMBRANE TRANSPORT PROTEIN FAMILIES SLC21 AND SLC22 IN ZEBRAFISH (DANIO RERIO Hamilton, 1822)

Polyspecific SLC21/SLCO and SLC22 (Solute carriers) membrane transporters are responsible for the uptake of various endo- and xenobiotics into the cell. Despite their crucial role in toxicological response of organisms, their ecotoxicological relevance has not been studied so far. We have identified 14 Slc21/Slco genes and 14 Slc22 genes in zebrafish (Danio rerio). Phylogenetic and tissue distribution analysis suggest that Oatp1d1, Oatp2b1, Oat3, Oat2c-e and Oct1 could be important for xenobiotic transport in fish. We have found that Oatp1d1 is a functional ortholog of human OATP1A2, 1B1 and 1C1 and is crucial for the transport of conjugated steroid hormones in zebrafish, as well as for the elimination of numerous environmental contaminants through liver.

SLC transporters; Danio rerio; phylogenetic analysis; expression; function; ADME

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