engleski

Relationship between autoantibodies combination, metabolic syndrome components and diabetic complications in autoimmune diabetes in adults

The aim of our study was to establish the possible association between double or triple antibody positivity and latent autoimmune diabetes (LADA) phenotype in the context of metabolic syndrome (MS) prevalence and its individual components. This cross-sectional study population comprised 69 islet cell antibody positive patients coming for their comprehensive annual review. Twenty five (36.2%) were male, mean age 51 years with disease duration 8 years. Twenty eight (40.58%) were positive only for GAD Abs, 26 (37.68%) were positive for ICA and GAD Abs and 15 (21.74%) were positive for GAD, ICA and IA2 Abs. The lowest value of waist circumference, MS and arterial hypertension (AH) prevalence was found in the group positive for all three antibodies. In the multinominal multivariate logistic regression model MS was negatively associated with triple Abs positivity compared to single Ab positivity, and compared to double Abs positive group. Our results highlight the importance of inverse association between simultaneous Abs positivity for ICA, GAD and IA2 with the MS and its components presence in LADA patients. This inverse relationship might implicate LADA patients phenotype closer to T1DM.

diabetes mellitus ; autoimmunity ; metabolic syndrome

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