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Pregled bibliografske jedinice broj: 700229

BPC 157 antagonized the general anesthetic potency of thiopental and reduced prolongation of anesthesia time induced by L-NAME/thiopental combination


Zemba, Mladen; Zemba Čilić; Andrea, Balenović, Igor; Drmić, Domagoj; Šuran, Jelena; Radić, Božo; Filipović, Marinko; Boban Blagaić, Alenka; Brčić, Luka; Kolenc, Danijela et al.
BPC 157 antagonized the general anesthetic potency of thiopental and reduced prolongation of anesthesia time induced by L-NAME/thiopental combination // Experimental Biology
San Diego, SAD, 2014. str. 1061.3-1061.3 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
BPC 157 antagonized the general anesthetic potency of thiopental and reduced prolongation of anesthesia time induced by L-NAME/thiopental combination

Autori
Zemba, Mladen ; Zemba Čilić ; Andrea, Balenović, Igor ; Drmić, Domagoj ; Šuran, Jelena ; Radić, Božo ; Filipović, Marinko ; Boban Blagaić, Alenka ; Brčić, Luka ; Kolenc, Danijela ; Seiwerth, Sven Seiwerth, Sikirić, Predrag ; Grabarević, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Experimental Biology

Mjesto i datum
San Diego, SAD, 26.4.-30.4

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Thiopental; BPC 157; L NAME

Sažetak
We hypothesized the general anesthetic thiopental effect depending on NO-related mechanisms, consequently counteracted by stable gastric pentadecapeptide BPC 157. (i) To determine the general anesthetic effect of thiopental and possible counteraction depending on BPC 157 administration, all rats received intraperitoneally thiopental (20, 30, 40 mg/kg) while medication (BPC 157 (10 μg/kg, 10 ng/kg, 10 pg/kg) was given intraperitoneally at 5 min before thiopental. (ii) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L- NAME (10 mg/kg), L-arginine (30 mg/kg) were applied alone and/or combined. BPC 157 was given at 25 min before thiopental while L-NAME, L- arginine, alone and/or combined, were applied at 20 min before thiopental. (i) BPC 157 (10 ng/kg and 10 μg/kg), caused significant antagonism of general anesthesia produced by thiopental with a parallel shift of the dose- response curve to the right. (ii) L-NAME. Thiopental-induced anesthesia duration was tripled. L-arginine. Active only given with L- NAME or BPC 157: habitual thiopental anesthesia time not influenced ; potentiating effects of L-NAME lessened, not abolished ; shortening effect of BPC 157: abolished. BPC 157 and L- NAME. Potentiating effects of L-NAME was abolished. L-NAME and L-arginine and BPC 157. L- NAME+L-arginine+BPC 157 rats exhibited values close to those in BPC 157 rats. Thiopental general anaesthesia is simultaneously manipulated in both ways with NO-system activity modulation, L-NAME (prolongation) and BPC 157 (shortening/counteraction). BPC 157 and L- arginine might serve two NO-system pathways, more or less active, alternatively activated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE