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The influence of the nucleotide excision-repair system on mutagenesis in Salmonella typhimurium LT2 after exposure to low doses of monofunctional alkylating agents (CROSBI ID 206418)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bačun-Družina, Višnja ; Matić, Ivan ; Matijašević, Zdenka ; Alačević, Marija The influence of the nucleotide excision-repair system on mutagenesis in Salmonella typhimurium LT2 after exposure to low doses of monofunctional alkylating agents // Mutation research, 264 (1991), 4; 207-212. doi: 10.1016/0165-7992(91)90080-N

Podaci o odgovornosti

Bačun-Družina, Višnja ; Matić, Ivan ; Matijašević, Zdenka ; Alačević, Marija

engleski

The influence of the nucleotide excision-repair system on mutagenesis in Salmonella typhimurium LT2 after exposure to low doses of monofunctional alkylating agents

The role of nucleotide excision repair in the mutagenicity of the monofunctional alkylating agents N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methyl methanesulfonate (MMS), N-ethyl-N'- nitro-N-nitrosoguanidine (ENNG), and N-ethyl-N- nitrosourea (ENU) in Salmonella typhimurium was examined. The mutagenic potential of the mutagenic agents used increased in the following order: MMS less than ENU less than ENNG less than MNNG. The results obtained confirm the involvement of nucleotide excision repair in the removal of mutagenic lesions from the DNA of S. typhimurium cells exposed to high doses of methylating as well as ethylating agents. At the low doses of all the alkylating agents used, the nucleotide excision repair-proficient strain was mutagenized more efficiently than the uvrB mutant. This phenomenon, a consequence of competition between nucleotide excision-repair enzymes and constitutive O6- methylguanine-DNA methyltransferase, is discussed.

monofunctional alkylating agents ; low doses ; nucleotide excision repair ; Uvr+-dependent mutagenesis

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Podaci o izdanju

264 (4)

1991.

207-212

objavljeno

0027-5107

1873-135X

10.1016/0165-7992(91)90080-N

Povezanost rada

Biotehnologija

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