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Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives (CROSBI ID 206405)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Gazivoda Kraljević, Tatjana ; Ilić, Nataša ; Stepanić, Višnja ; Sappe, Lana ; Petranović, Jasna ; Kraljević Pavelić, Sandra ; Raić-Malić, Silvana Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives // Bioorganic & medicinal chemistry letters, 24 (2014), 13; 2913-2917. doi: 10.1016/j.bmcl.2014.04.079

Podaci o odgovornosti

Gazivoda Kraljević, Tatjana ; Ilić, Nataša ; Stepanić, Višnja ; Sappe, Lana ; Petranović, Jasna ; Kraljević Pavelić, Sandra ; Raić-Malić, Silvana

engleski

Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives

A series of novel N-alkylated C-6-isobutyl- or -propyl pyrimidine derivatives were synthesized and their antiproliferative effect was evaluated on a panel of tumor cell lines including leukemia cell line K562 and normal diploid human fibroblasts. N-methoxymethylated 5-methylpyrimidin-2, 4-dione with di(benzyloxy)isobutyl at C-6 (14b) showed the strongest effect on the cell growth at micromolar concentrations. Mechanisms of action for the lipophilic compound 14b predicted in silico, pointed to its anticancer and antimetastatic potential exerted through inhibition of DNA or RNA polymerases and adhesion molecules. The latter mechanism has been supported in vitro for adherent tumor cell lines.

N-Alkylated pyrimidine derivatives ; C-6-isobutyl pyrimidine ; C-6-propyl pyrimidine ; In silico analysis ; Antiproliferative evaluation

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Podaci o izdanju

24 (13)

2014.

2913-2917

objavljeno

0960-894X

1464-3405

10.1016/j.bmcl.2014.04.079

Povezanost rada

Kemija

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