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Pregled bibliografske jedinice broj: 699856

Function of circle of Willis

Vrselja, Zvonimir; Brkić, Hrvoje; Mrđenović, Stefan; Radić, Radivoje; Ćurić, Goran
Function of circle of Willis // Journal of cerebral blood flow and metabolism, 34 (2014), 4; 578-584 doi:10.1038/jcbfm.2014.7 (međunarodna recenzija, članak, znanstveni)

Function of circle of Willis

Vrselja, Zvonimir ; Brkić, Hrvoje ; Mrđenović, Stefan ; Radić, Radivoje ; Ćurić, Goran

Journal of cerebral blood flow and metabolism (0271-678X) 34 (2014), 4; 578-584

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Atherosclerosis; cerebrovascular disease; comparative anatomy; evolution; pulse wave analysis; redundancy

Nearly 400 years ago, Thomas Willis described the arterial ring at the base of the brain (the circle of Willis, CW) and recognized it as a compensatory system in the case of arterial occlusion. This theory is still accepted. We present several arguments that via negativa should discard the compensatory theory. (1) Current theory is anthropocentric ; it ignores other species and their analog structures. (2) Arterial pathologies are diseases of old age, appearing after gene propagation. (3) According to the current theory, evolution has foresight. (4) Its commonness among animals indicates that it is probably a convergent evolutionary structure. (5) It was observed that communicating arteries are too small for effective blood flow, and (6) missing or hypoplastic in the majority of the population. We infer that CW, under physiologic conditions, serves as a passive pressure dissipating system ; without considerable blood flow, pressure is transferred from the high to low pressure end, the latter being another arterial component of CW. Pressure gradient exists because pulse wave and blood flow arrive into the skull through different cerebral arteries asynchronously, due to arterial tree asymmetry. Therefore, CW and its communicating arteries protect cerebral artery and blood brain barrier from hemodynamic stress.

Izvorni jezik

Znanstvena područja
Biologija, Temeljne medicinske znanosti


Medicinski fakultet, Osijek

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus