engleski

Clinical and pathophysiological significance of antineutrophil cytoplasmic autoantibodies (ANCA) in vasculitis

Antineutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 or myeloperoxidase are strongly associated with the ANCA-associated vasculitides-Wegener's granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome. They produce either perinuclear or cytoplasmic fluorescence pattern on ethanol-fixed neutrophils by indirect immunofluorescence. ANCA are useful tolls for diagnosing and monitoring primary small vessel vasculitides. ANCA testing is a highly sensitive and specific test for making a diagnosis of WG, MPA or CSS. In these patients, ANCA titers are related to disease activity and a rise in titer may precede a clinical relapse. Several findings indicate that ANCA and their target antigens may be implicated in the patogenesis of primary small vessel vasculitides. This evidence comes from clinical observations, in vitro and in vivo experiments.

antineutrophil cytoplasmic autoantibodies (ANCA), vasculitis

nije evidentirano