Napredna pretraga

Pregled bibliografske jedinice broj: 699000

In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis


Lalani, Tahaniyat; Chu, Vivian H.; Park, Lawrence P.; Cecchi, Enrico; G. Corey, Ralph; Durante-Mangoni, Emanuele; Fowler, Vance G., Jr; Gordon, David; Grossi, Paolo; Hannan, Margaret et al.
In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis // JAMA. Journal of the American Medical Association, 173 (2013), 16; 1495-1500 doi:10.1001/jamainternmed.2013.8203 (međunarodna recenzija, članak, znanstveni)


Naslov
In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis

Autori
Lalani, Tahaniyat ; Chu, Vivian H. ; Park, Lawrence P. ; Cecchi, Enrico ; G. Corey, Ralph ; Durante-Mangoni, Emanuele ; Fowler, Vance G., Jr ; Gordon, David ; Grossi, Paolo ; Hannan, Margaret ; Hoen, Bruno ; Muñoz, Patricia ; Rizk, Hussien ; Kanj, Souha S. ; Selton-Suty, Christine ; Sexton, Daniel J. ; Spelman, Denis ; Ravasio, Veronica ; Tripodi, Marie Françoise ; Wang, Andrew ; ... ; Baršić, Bruno ; Bukovski, Suzana ; Krajinović, Vladimir ; Pangerčić, Ana ; Rudež, Igor ; Vincelj, Josip ; ...

Izvornik
JAMA. Journal of the American Medical Association (0098-7484) 173 (2013), 16; 1495-1500

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Endocarditis; Prosthetic valve; Surgery

Sažetak
To determine the in-hospital and 1-year mortality in patients with PVE who undergo valve replacement during index hospitalization compared with patients who receive medical therapy alone, after controlling for survival and treatment selection bias. Participants were enrolled between June 2000 and December 2006 in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE- PCS), a prospective, multinational, observational cohort of patients with infective endocarditis. Patients hospitalized with definite right- or left-sided PVE were included in the analysis. We evaluated the effect of treatment assignment on mortality, after adjusting for biases using a Cox proportional hazards model that included inverse probability of treatment weighting and surgery as a time- dependent covariate. The cohort was stratified by probability (propensity) for surgery, and outcomes were compared between the treatment groups within each stratum. Of the 1025 patients with PVE, 490 patients (47.8%) underwent early surgery and 535 individuals (52.2%) received medical therapy alone. Compared with medical therapy, early surgery was associated with lower in-hospital mortality in the unadjusted analysis and after controlling for treatment selection bias (in- hospital mortality: hazard ratio [HR], 0.44 [95% CI, 0.38-0.52] and lower 1-year mortality: HR, 0.57 [95% CI, 0.49-0.67]). The lower mortality associated with surgery did not persist after adjustment for survivor bias (in- hospital mortality: HR, 0.90 [95% CI, 0.76- 1.07] and 1-year mortality: HR, 1.04 [95% CI, 0.89-1.23]). Subgroup analysis indicated a lower in-hospital mortality with early surgery in the highest surgical propensity quintile (21.2% vs 37.5% ; P = .03). At 1-year follow- up, the reduced mortality with surgery was observed in the fourth (24.8% vs 42.9% ; P  = .007) and fifth (27.9% vs 50.0% ; P = .007) quintiles of surgical propensity. Prosthetic valve endocarditis remains associated with a high 1-year mortality rate. After adjustment for differences in clinical characteristics and survival bias, early valve replacement was not associated with lower mortality compared with medical therapy in the overall cohort. Further studies are needed to define the effect and timing of surgery in patients with PVE who have indications for surgery.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
International Collaboration on Endocarditis–Prospective Cohort Study Investigators.



POVEZANOST RADA


Projekt / tema
108-1080002-0102 - Procjena potrebe i učinkovitosti liječenja teških infekcija u JIM (Bruno Baršić, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinička bolnica "Dubrava",
Zdravstveno veleučilište, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Scopus


Citati