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Association between valvular surgery and mortality among patients with infective endocarditis complicated by severe sepsis and septic shock


Krajinović, Vladimir; Raffanelli, Dinko; Rudež, Igor; Vincelj, Josip; Baršić, Bruno
Association between valvular surgery and mortality among patients with infective endocarditis complicated by severe sepsis and septic shock // Abstracts from the 12 International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections ; u: International Journal of Antimicrobial Agents 41 (2013) (S1) S1-S37 ; P24
Dubrovnik, Hrvatska, 2013. str. S14-S14 (poster, nije recenziran, sažetak, znanstveni)


Naslov
Association between valvular surgery and mortality among patients with infective endocarditis complicated by severe sepsis and septic shock

Autori
Krajinović, Vladimir ; Raffanelli, Dinko ; Rudež, Igor ; Vincelj, Josip ; Baršić, Bruno

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts from the 12 International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections ; u: International Journal of Antimicrobial Agents 41 (2013) (S1) S1-S37 ; P24 / - , 2013, S14-S14

Skup
International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections (12 ; 2013)

Mjesto i datum
Dubrovnik, Hrvatska, 19.–21.05.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Infective endocarditis; cardiac surgery; sepsis
(IInfective endocarditis; cardiac surgery; sepsis)

Sažetak
Severe sepsis and septic shock are common complications of infective endocarditis (IE). A prospective, single-center observational study in patients with definite native or prosthetic valve IE admitted between January 1, 2000 and December 31, 2011. The main objective of the study was estimate the safety of valve replacement in patients with severe sepsis and/or septic shock and its impact on patients' outcome. We compared clinical characteristics and outcome (in-hospital mortality)in surgically and only medically treated patients stratified on the severity of sepsis. The cohort included 294 patients with definite IE known septic status enrolled. Patients were stratified into two groups. There were 95 (32.3%) patients with severe sepsis and/or septic shock (SSS) and 199 (67.7%) with sepsis (S). Valve replacement was performed in 37(38.9%) patients in the SSS group, and 71 (35.7%) in the S group, p=0.587. APACHE II score was significantly higher among medically treated patients. The mortality in SSS group was significantly higher in medically treated patients, 39/58 (67.2%) vs. 5/37 (13.4%), p<0.001. After adjusting for APACHE II score, SOFA score, age, and congestive heart failure, the beneficial impact of cardiac surgery remained significant. Cardiac surgery decreased the risk of in-hospital death about five times in SSS group, OR=0.096, 95%CI 0.027-0.335. Even in the most severe septic patients with IE, cardiac surgery improves patients' outcome. SOFA score is a better predictor of patients' outcome than APACHE II score, and should be included in the evaluation of IE patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Doi:10.1016/S0924-8579(13)70048-7



POVEZANOST RADA


Projekt / tema
108-1080002-0102 - Procjena potrebe i učinkovitosti liječenja teških infekcija u JIM (Bruno Baršić, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinička bolnica "Dubrava",
Zdravstveno veleučilište, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE