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Pregled bibliografske jedinice broj: 698281

Most common HCV genotypes in patients from north- eastern Croatia


Perić, Magdalena; Bošnjak, Zinka; Džijan, Snježana; Šarkanj, Bojan; Barbić, Jerko; Roksandić Križan, Ivana; Ružman, Nataša; Vuković, Dubravka
Most common HCV genotypes in patients from north- eastern Croatia // Acta Medica Academica, 43 (2014), 1; 10-18 doi:10.5644/ama2006-124.95 (međunarodna recenzija, članak, znanstveni)


Naslov
Most common HCV genotypes in patients from north- eastern Croatia

Autori
Perić, Magdalena ; Bošnjak, Zinka ; Džijan, Snježana ; Šarkanj, Bojan ; Barbić, Jerko ; Roksandić Križan, Ivana ; Ružman, Nataša ; Vuković, Dubravka

Izvornik
Acta Medica Academica (1840-1848) 43 (2014), 1; 10-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HCV-RNA ; HCV genotypes ; HCV antibody-positive ; Risk factors

Sažetak
Objective. The aims of this study were to determine the HCV-RNA viral load, genotype distribution, risk factors and symptoms of HCV-RNA positive viral load in HCV antibody-positive patients from north-eastern Croatia. Materials and methods. From January 2009 to December 2011, 203 HCV antibody- positive patients (130 men and 73 women ; median age 44.5 years) were analyzed for HCV-RNA by the COBAS TaqMan HCV test and genotyped by the Linear Array HCV Genotyping test (both from Roche). All patients completed a structured questionnaire about risk factors and symptoms. Results. The HCV-RNA percentage was 61.1% and was similar for men and women. The HCV-RNA viral load increased with age: while 55% of 20-50 year old patients were HCV-RNA positive, 73% of patients >50 years were positive (p=0.021). Genotype 1 was the most prevalent genotype (79.8%), followed by 3 (12.9%), 4 (6.5%), and 2 (0.8%) ; genotypes 5 and 6 were not determined. Patients with genotype 1 (median, 50 years) were older than patients with 3 (median, 33.5 years) or 4 (median, 38 years). The blood transfusions performed in Croatian hospitals before 1993 was significantly associated with HCV- RNA positive viral load (p<0.05). Conclusion. These data indicated an elevated prevalence of genotype 1 in elderly HCV-RNA positive patients and it may continue to rise. Using RNA-based detection in HCV positive-antibody patients would allow early detection of HCV in the acute stage of HCV disease and the increased risk of HCV genotype-related treatment failure.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove
Prehrambeno-tehnološki fakultet, Osijek,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar"

Citiraj ovu publikaciju

Perić, Magdalena; Bošnjak, Zinka; Džijan, Snježana; Šarkanj, Bojan; Barbić, Jerko; Roksandić Križan, Ivana; Ružman, Nataša; Vuković, Dubravka
Most common HCV genotypes in patients from north- eastern Croatia // Acta Medica Academica, 43 (2014), 1; 10-18 doi:10.5644/ama2006-124.95 (međunarodna recenzija, članak, znanstveni)
Perić, M., Bošnjak, Z., Džijan, S., Šarkanj, B., Barbić, J., Roksandić Križan, I., Ružman, N. & Vuković, D. (2014) Most common HCV genotypes in patients from north- eastern Croatia. Acta Medica Academica, 43 (1), 10-18 doi:10.5644/ama2006-124.95.
@article{article, year = {2014}, pages = {10-18}, DOI = {10.5644/ama2006-124.95}, keywords = {HCV-RNA, HCV genotypes, HCV antibody-positive, Risk factors}, journal = {Acta Medica Academica}, doi = {10.5644/ama2006-124.95}, volume = {43}, number = {1}, issn = {1840-1848}, title = {Most common HCV genotypes in patients from north- eastern Croatia}, keyword = {HCV-RNA, HCV genotypes, HCV antibody-positive, Risk factors} }

Časopis indeksira:


  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CAB Abstracts
  • MEDLINE


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