engleski

Laboratory tests of renal function: today and tomorrow

The laboratory tests of renal function are currently based on serum and/or urine determinations of established biochemical markers, mainly creatinine or BUN. These convential markers are not ideal, providing non-specific and late estimation of renal function which limits the therapeutic options and may compromise the outcome. It is accepted that they may be unable to detect any acute injury or process. This has led to research to find more reliable renal biomarkers. The most promising of the new serum biomarkers are cystatin C, neutrophil gelatinase-associated lipocalin and fatty acid-binding proteins. Urinary markers as N-acetyl-β-D-glucosaminidase, IL-18 or kidney injury molecule 1 may represent an early, noninvasive biomarker for renal injury. The discovery of new biomarkers of kidney function gives hope that they could substantially change the treatment strategies in acute injuries long before permanent damage has set in.

Renal function ; biomarkers

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