engleski

Cobalamin Deficiency Manifested with Seizures, Mood Oscillations, Psychotic Features and Reversible Dementia in the Absence of Typical Neurologic and Hematologic Signs and Symptoms: A Case Report

Cobalamin deficiency is associated with a wide spectrum of hematologic, neurologic, gastroenterologic and psychiat- ric disorders or symptoms. We report a case of a 50-year-old man with complex partial seizures with secondary general- ization, mood oscillations and psychotic symptoms alternating with confusion and reversible dementia secondary to cobalamin deficiency in the absence of typical neurologic and/or hematologic symptoms and signs. Exclusion of epilepsy, acute, atrophic or expansive lesion of central nervous system and usual etiology associated with reversible dementia (in- fectious diseases, an endocrine etiology and deficiency of vitamins other than cobalamin) ; finding of cobalamin defi- ciency only and complete neuropsychiatric recovery after substitution, confirmed etiology. Typical and atypical psychiat- ric manifestations due to cobalamin deficiency that precede neurologic and/or hematologic signs and symptoms can recover completely after adequate replacement therapy. Key

mood oscillations; delusions; auditory hallucinations; dementia; cobalamin deficiency

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